ASSESSMENT OF ADHERENCE TO TREATMENT OF PATIENTS WITH HIV INFECTION

Traditionally, the success of treatment is associated with the patient's awareness of the need for treatment, regular observation in medical specialized institutions and the mastery of certain social, professional, neurocognitive and other skills. The result of treatment of a patient with HIV infection also depends on these factors, especially at the present time, during the HIV epidemic.

The aim of the research. To assess adherence to treatment in patients with HIV infection depending on the presence of pulmonary tuberculosis using a universal questionnaire for quantitative assessment of treatment adherence.

Materials and methods. The study involved 106 patients with HIV infection and 106 patients with tuberculosis, on the background of HIV infection, who were treated in a hospital. An anonymous survey was conducted using the universal Russian questionnaire for the quantitative assessment of adherence to treatment. The authors added questions of a social nature to the questionnaire. In the groups, the patients were comparable in terms of gender, age, drug history. For comparison, the nonparametric Mann-Whitney test was used. Correlation analysis was carried out to determine the influencing factors.

Results. Adherence to drug therapy was the lowest observed in HIV-infected patients with pulmonary tuberculosis. Medium and high levels of adherence were more often observed in the main group of patients with HIV infection. A similar situation was observed in the analysis of adherence to medical support. Adherence to lifestyle modification was the highest in patients in the main group. When assessing the integral adherence to treatment in the main group of patients with HIV infection, an average and high level was observed in almost half of the patients.

When conducting a correlation analysis, a number of factors were identified that influenced the formation of all types of adherence.

Conclusion. The results revealed two main categories of factors influencing the formation of adherence to treatment in patients with HIV infection. Medical factors: primary hospitalization in a hospital and the absence of a secondary disease; social: minor children, monthly material income, HIV-negative sexual partner. The results of this study confirm the need to rethink the formation of patient flows, the selection of newly identified patients and work with this contingent to improve adherence to treatment.

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