Neutrophil-to-lymphocyte ratio in patients with liver cirrhosis depending on the outcome of hospitalization
https://doi.org/10.52485/19986173_2023_1_17
Abstract
The aim of the research. Assess the functional state of the liver, MELD and Child-Pugh indices, neutrophil-to-lymphocyte ratio (NLR) in patients with liver cirrhosis, depending on the outcome of hospitalization; apply the NLR indicator in one’s own clinical practice.
Materials and methods. 69 patients diagnosed with liver cirrhosis were examined. A standard examination was performed (CBC and biochemical blood tests, ultrasound, upper endoscopy), Child-Pugh and MELD indices, NLR index (by dividing the absolute number of neutrophils by the absolute number of lymphocytes) were calculated for each patient.
Results. Patients were divided into two groups depending on the outcome of hospitalization: survivors (47/68 %) and dead (22/32 %). The groups did not differ in sex and age, in the portal hypertension severity. Among dead patients higher Child-Pugh [13 (12-13) vs 10 (8-11); p < 0.0001] and MELD indices [28 (25-34.5) vs 13 (9-18); p < 0.0001] were naturally observed. The NLR index was also significantly higher among dead patients with liver cirrhosis: 12.8 (5.7-18.7) vs 2.6 (1.8-3.8) (p < 0.0001). Low NLR (less than 1) was equally common in both groups: 8.5 % vs 4.6 % (p = 0.55); from 1 to 6 more often occurred in the group of survivors: 80.9 % vs 22.7 % (p < 0.0001); more than 6 - significantly more common in the group of dead patients: 72.7 % vs 10.6 % (p < 0.0001). A positive statistically significant correlation was found between the NLR index and CRP (ρ = 0.67; p < 0.05), NLR and MELD (ρ = 0.52; p < 0.05).
Conclusion. Thus, NLR proved to be a good and accessible indicator of the risk of a lethal outcome among patients with decompensated liver cirrhosis during the current hospitalization. NLR more than 6 can be used in wide clinical practice as a predictor of adverse outcome in the current hospitalization in patients with liver cirrhosis.
Supporting agencies: The study was not funded by anyone
About the Authors
A. V. Davydova
Irkutsk State Medical University
Russian Federation
Russian Federation
664003; 1 Krasnogo Vosstaniya street; Irkutsk
V. A. Dul'skiy
Irkutsk State Medical University
Russian Federation
Russian Federation
664003; 1 Krasnogo Vosstaniya street; Irkutsk
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Review
For citations:
Davydova A.V., Dul'skiy V.A. Neutrophil-to-lymphocyte ratio in patients with liver cirrhosis depending on the outcome of hospitalization. Transbaikalian Medical Bulletin. 2023;(1):17-24. (In Russ.) https://doi.org/10.52485/19986173_2023_1_17
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