Nutritional changes in patients with new coronavirus infection
https://doi.org/10.52485/19986173_2022_4_69
Abstract
The aim. Detection of changes in nutritional status in patients with moderate and severe novel coronavirus infection (COVID-19).
Methods. On the basis of the Regional Clinical Infectious Diseases Hospital of Perm in 2020 - 2021. A comprehensive clinical and laboratory study was conducted to study the nutritional status in 246 patients with a new coronavirus infection (COVID-19). Of these, the first group - 142 people. with a moderate course – was treated in the infectious diseases department, the second group - 104 people. with a severe course – hospitalized in the intensive care unit. On days 1, 10, and 21, the nutritional status was assessed in patients with COVID-19 using anthropometric, laboratory, and clinical methods to assess the somatic protein pool, identify the degree of nutritional deficiency and the severity of systemic disorders.
Results. At the time of admission, nutritional status disorders from mild to severe were recorded in both groups. By the 10th day of hospitalization, all patients showed a decrease in the amount of visceral pool proteins - total protein, albumin, transferrin, which indicates their active consumption as part of the formation of hypermetabolism syndrome - hypercatabolism, regardless of the severity of the disease. An increase in the main laboratory markers of liver and kidney failure was recorded, as well as the dependence of these dysfunctions on the identified lack of protein macronutrients, which was a predictor of the severe course of COVID-19.
Conclusion. COVID-19 has a direct impact on the development of severe metabolic disorders and the formation of nutritional insufficiency, therefore, nutritional support should be a mandatory component of therapy for patients, regardless of the severity of the disease.
About the Authors
V. V. Nikolenko
E.A. Wagner State Medical University of Perm
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614000
I. N. Prelous
E.A. Wagner State Medical University of Perm
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614000
E. V. Belkina
E.A. Wagner State Medical University of Perm
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614000
N. N. Vorobeva
E.A. Wagner State Medical University of Perm
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614000
A. P. Nebolsina
Perm Regional Clinical Infectious Diseases Hospital
Russian Federation
Russian Federation
96 Pushkina str., Perm, 614990
References
1. Luft V.M., Afonchikov V.S., Dmitriev A.V., Erpuleva E.V., Lapitskiy A.V., Lekmanov A.U., Luft A.V., Nazarov V.I., Popova T.S., Rasnovskaya N.F., Sergeeva A.M., Tropskaya N.S., Trofimov P.A., Shestopalov A.E. Clinical Nutrition Guide. M.: «Art-Ekspress». 3-e izd. 2016. 492. in Russian.
2. Nikolenko A.V, Leyderman I.N., Nikolenko V.V. Screening of key markers of protein and micronutrient metabolism in icu patients with acute pathology of the abdominal organs. Vestnik intensivnoy terapii imeni A.I. Saltanova. 2019. 4.81-87. DOI: 10.21320/1818-474X-2019-4-81-87. in Russian.
3. Leyderman I.N., Yaroshetskiy A.I. Discussing protein requirements of intensive care unit (ICU) patients. Alexander Saltanov Intensive Care Herald. 2018. 3.59-66. DOI: 10.21320/1818-474X-2018-3-59-66. in Russian.
4. Nikolenko V.V., Belkina E.V., Prelous I.N., Yakusheva M.V., Zernina M.G., Golikova E.V. Changes in nutritional status in vaccinated and unvaccinated patients with COVID-19 coronavirus infection. In: Infectious Diseases in the Modern World: Evolution, Current and Future Threats. Proceedings of the XIV Annual All-Russian Congress on infectious diseases named after Academician V.I. Pokrovsky, Moscow, 2022. 122-123. in Russian.
5. Metabolic monitoring and nutritional support during long-term mechanical ventilation. All- Russian public organization "Federation of anesthesiologists and resuscitators" Clinical recommendations. Approved by the FAR Presidium on September 8, 2018. Available from: http://far.org.ru/recomendation download Anutrition ventilation, Access date 02.06.2021. in Russian.
6. Khubutia M.Sh., Popova T.S., Saltanova A.I. Parenteral and enteral nutrition: National guidelines. M., GEOTAR-Media, 2014. in Russian.
7. Grechko A.V., Evdokimov E.A., Kotenko O.N., Krylov K.Yu., Kryukov E.V., Luft V.M., Nikityuk D.B., Petrikov S.S., Petrova M.V., Pogozheva A.V., Popova T. S., Protsenko D.N., Ryk A.A., Sviridov S.V., Starodubova A.V., Stets V.V., Tarmaeva I.Yu ., Tutelyan V.A., Sharafetdinov Kh.Kh., Shestopalov A.E., Yakovleva A.V. Nutritional support for patients with coronavirus infection COVID-19 A.V. Clinical nutrition and metabolism. 2020. 1(2).56–91. DOI: https://doi.org/10.36425/clinnutrit42278 in Russian.
8. Pasechnik I.N. Nutritional support of critically ill patients with coronavirus infection. Russian Journal of Anaesthesiology and Reanimatology Anesteziologiya I Reanimatologiya. 2020.3.70- 75. https://doi.org/10.17116/anaesthesiology202003175 in Russian.
9. World Health Organization. Recommendations for the Management of Severe Acute Respiratory Infection (SARI) for Suspected COVID-19: Interim Guidance (translation into Russian from March 21, 2020). Available from: https://ott.ru/files/news/common/2020/20200317_karantin/voz_covid_19_vremennoerukovodstvo_13032020.pdf. in Russian.
10. Practical Nutrition Guidelines for Persons with SARS-CoV-2 Infection and Other Statements from European Association for Clinical Nutrition and Metabolism Experts Rocco Barazzoni, Stephan C Bischoff, Zeljko Krznaric, Matthias Pirlich, Pierre Singer; approved by the ESPEN Council. DOI: https://doi.org/10.1016/j.clnu.2020.03.022.
11. Ministry of health of the Russian Federation. Ministry of Health of the Russian Federation. Temporary guidelines. Prevention, diagnosis and treatment of a new coronavirus infection.Version 4-6 (27.03.2020). Available from: https://static3.rosminzdrav.ru/system/attachments/attaches/000/049/877/original/COVID19_recomend_v4.pdf/ in Russian.
12. Bychinin M.V., Antonov I.O., Klypa T.V., Mandel I.A., Minets A.I., Kolyshkina N.A., Golobokova Y.B. Nosocomial Infection in Patients with Severe and Critical COVID-19. General Reanimatology. 2022.18(1).4-10. DOI: 10.15360/1813-9779-2022-1-4-10.
13. Intensive care: National leadership. Brief edition. Eds. B.R. Gelfand, I.B. Zabolotskikh. 2nd ed., revised and additional. M.: GEOTAR-Media, 2019. in Russian.
14. Fundamentals of clinical nutrition. Lecture materials for the courses of the European Association for Parenteral Nutrition. Ed. L. Sobotki. M., 2015. in Russian.
15. Leiderman I.N., Lesteva N.A., Kasherininov I.Yu., Kuzmin A.S., Ahimov P.S., Barinova S.A., Kanshaov N.Z., Mazurok V.A. Prognostic value of serum albumin and urea nitrogen excretion in COVID-19 ICU patients: a singlecenter, prospective, cohort study. Alexander Saltanov Intensive Care Herald. 2021. 3. 61–68. (In Russ) DOI:10.21320/1818-474X-2021-3-61-68 in Russian.
Review
For citations:
Nikolenko V.V., Prelous I.N., Belkina E.V., Vorobeva N.N., Nebolsina A.P. Nutritional changes in patients with new coronavirus infection. Transbaikalian Medical Bulletin. 2022;(4):69-78. (In Russ.) https://doi.org/10.52485/19986173_2022_4_69
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