zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2021_3_93zabmedvestnik-92Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSKIR6.2 СУБЪЕДИНИЦА АТФ - ЧУВСТВИТЕЛЬНОГО КАЛИЕВОГО КАНАЛА: ФИЗИОЛОГИЧЕСКОЕ ЗНАЧЕНИЕ, ГЕНЕТИЧЕСКИЕ МУТАЦИИKIR6.2 SUBUNIT OF THE ATP-SENSITIVE POTASSIUM CHANNEL: PHYSIOLOGICAL ROLE, GENETIC MUTATIONSФёдороваА. П.FyodorovaA. P.

672000, г. Чита, ул. Горького, 39а

39a Gorky str., Chita, 672000

ЗайцевД. Н.ZaytsevD.  N.

672000, г. Чита, ул. Горького, 39а

39a Gorky str., Chita, 672000

СеребряковаО. В.SerebryakovaO. V.

672000, г. Чита, ул. Горького, 39а

39a Gorky str., Chita, 672000

Федеральное государственное бюджетное образовательное учреждение высшего образования «Читинская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияChita State Medical AcademyRussian Federation2021010820240393100Copyright © Фёдорова А.П., Зайцев Д.Н., Серебрякова О.В., 20242024Фёдорова А.П., Зайцев Д.Н., Серебрякова О.В.Fyodorova A.P., Zaytsev D.N., Serebryakova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/92

В обзоре приведены сведения о строении АТФ-чувствительных калиевых каналов, принципе их функционирования. Представлена современная информация о физиологической роли субъединицы Kir6.2 АТФ-чувствительных калиевых каналов в различных тканях. Приводится патология, связанная с мутациями в гене KCNJ11, регулирующем работу Kir6.2.

This review contains information about the structure and principles of functioning of ATP-sensitive potassium channels. The article presents information about the physiological role of the Kir6.2 subunit of ATP-sensitive K + channels in various tissues, and the pathology associated with mutations in the KCNJ11 gene, which regulates the work of Kir6.2.

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The authors declare that there are no conflicts of interest present.