zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2026_1_140zabmedvestnik-533Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSРоль тромбоцитов в онкогенезе: механизмы взаимодействия с опухолевыми клеткамиThe role of platelets in oncogenesis: mechanisms of interaction with tumor cellshttps://orcid.org/0000-0001-9918-4417МарковскийА. В.MarkovskyA. V.

Александр Викторович Марковский, к. м. н., научный сотрудник

Научно-исследовательский институт молекулярной медицины; лаборатория молекулярной генетики 

672000; ул. Горького, 39а; Чита

candidate of Medical Sciences, researcher, junior research fellow

Research Institute of Molecular Medicine; Laboratory of Molecular Genetics

672000; 39a Gorky St.; Chita

sorcerer-asy@mail.ruhttps://orcid.org/0009-0002-3336-2553ГурулеваО. А.GurulevaO. A.

Ольга Александровна Гурулева, студентка

Лечебное дело

672000; ул. Горького, 39а; Чита

student

Faculty of General Medicine

672000; 39a Gorky St.; Chita

gurulevao@icloud.comhttps://orcid.org/0009-0004-5949-8170КолобоваА. В.KolobovaA. V.

Ангелина Владимировна Колобова, студентка

Лечебное дело

672000; ул. Горького, 39а; Чита

student

Faculty of General Medicine

672000; 39a Gorky St.; Chita

chareot@mail.ruФГБОУ ВО «Читинская государственная медицинская академия» Министерства здравоохранения РФРоссияChita State Medical AcademyRussian Federation20261905202601140151Copyright © Марковский А.В., Гурулева О.А., Колобова А.В., 20262026Марковский А.В., Гурулева О.А., Колобова А.В.Markovsky A.V., Guruleva O.A., Kolobova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/533

   В обзоре систематизированы современные данные о ключевой роли тромбоцитов в прогрессировании онкологических заболеваний. Детально проанализированы механизмы, выходящие за рамки гемостаза: активация тромбоцитов опухолевыми клетками (TCIPA) и их роль в создании прокоагулянтного состояния; стимуляция ангиогенеза через секрецию VEGF, PDGF и других факторов; прямое влияние на метастатический каскад через образование стабилизирующих агрегатов с циркулирующими опухолевыми клетками и опосредованное нарушение целостности эндотелиального барьера через АТФ/P2Y2-сигнальный путь.

   Особое внимание уделено молекулярным основам рак-ассоциированного тромбоза, включая вклад микровезикул (PDMP) и синдрома Труссо.

   Обсуждается петля положительной обратной связи «опухоль — тромбоциты», опосредованная выработкой IL-6 и тромбопоэтина.

   Сделан вывод, что тромбоциты являются активным участником опухолевой прогрессии, а их таргетинг представляет перспективное направление для адъювантной терапии.

   This review systematizes current data on the pivotal role of platelets in cancer progression. It details mechanisms beyond hemostasis: platelet activation by tumor cells (TCIPA) and their contribution to a procoagulant state; stimulation of angiogenesis via the secretion of VEGF, PDGF, and other factors; and the direct promotion of metastasis through the formation of protective aggregates with circulating tumor cells and ATP/P2Y2-mediated disruption of the endothelial barrier.

   Specific focus is given to the molecular basis of cancer-associated thrombosis, including the role of platelet-derived microparticles (PDMP) and Trousseau's syndrome.

   The positive feedback loop of the "tumor-platelet axis", mediated by IL-6 and thrombopoietin production, is discussed.

   It is concluded that platelets are active participants in tumor progression, and their targeting represents a promising avenue for adjuvant therapy.

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The authors declare that there are no conflicts of interest present.