zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2025_2_140zabmedvestnik-444Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSПаттерн циркулирующих микрорнк при остром инфаркте миокардаThe pattern of circulating micrornas in acute myocardial infarctionhttps://orcid.org/0000-0002-8493-0058ПетроваМ. М.PetrovaМ. М.

д. м. н., профессор, заведующая кафедрой

кафедра поликлинической терапии и семейной медицины с курсом ПО

660022; ул. Партизана Железняка, 1; Красноярск

Researcher ID: L-5623-2014; Elibrary (Author ID): 613080; Author ID (Scopus): 23987271200

Doctor of Medical Sciences, Professor, Head of the Department

Department Polyclinic Therapy with Course of Postgraduate Education

660022; 1 Partizan Zheleznyak St.; Krasnoyarsk

Researcher ID: L-5623-2014; Elibrary (Author ID): 613080; Author ID (Scopus): 23987271200

stk99@yandex.ruhttps://orcid.org/0000-0002-2840-837XШнайдерН. А.ShnayderN. A.

д. м. н., профессор, главный научный сотрудник, ведущий научный сотрудник

Институт персонализированной психиатрии и неврологии; центрколлективного пользования «Молекулярные и клеточные технологии»

660022; ул. Партизана Железняка, 1; Красноярск; 192019;  ул. Бехтерева, 3; Санкт-Петербург

Researcher ID: M-7084-2014; Elibrary (Author ID): 185359; Author ID (Scopus): 24503222300

Doctor of Medical Sciences, Professor, General Researcher, Leading Researcher

Institute of Personalized Psychiatry and Neurology; Center of Collective Usage«Molecular and Cell Technologies»

660022; 1 Partizan Zheleznyak St.; Krasnoyarsk; 192019; 3 Bekhterev St.; St. Petersburg

Researcher ID: M-7084-2014; Elibrary (Author ID): 185359; Author ID (Scopus): 24503222300

naschnaider@yandex.ruhttps://orcid.org/0000-0003-4639-6365ДмитренкоД. В.DmitrenkoD. V.

д. м. н., доцент, заведующий кафедрой, заведующий центром, заведующийлабораторией

ИПО; кафедра медицинской генетики и клинической нейрофизиологии; неврологический центр эпилептологии, нейрогенетики и исследованиямозга; лаборатория медицинской генетики

660022; ул. Партизана Железняка, 1; Красноярск

Researcher ID: H-7787-2016; Elibrary (Author ID): 614958; Author ID (Scopus): 55413907300

Doctor of Medical Sciences, Associate Professor, Head of the Department, Head of the Center, Head of the Laboratory

IPE; Department of Medical Genetics and Clinical Neurophysiology; Neurological Center for Epileptology, Neurogenetics and Brain Research; Laboratory of Medical Genetics

660022; 1 Partizan Zheleznyak St.; Krasnoyarsk

Researcher ID: H-7787-2016; Elibrary (Author ID): 614958; Author ID (Scopus): 55413907300

mart2802@yandex.ruhttps://orcid.org/0000-0003-2757-4875ПетровА. В.PetrovA. V.

студент

660022; ул. Партизана Железняка, 1; Красноярск

Researcher ID: AGZ-3730-2022; Elibrary (Author ID): 1154385; Author ID (Scopus): 5737505540

Student

660022; 1 Partizan Zheleznyak St.; Krasnoyarsk

Researcher ID: AGZ-3730-2022; Elibrary (Author ID): 1154385; Author ID (Scopus): 5737505540

artvpetrov@mail.ruhttps://orcid.org/0000-0002-0794-2530КаскаеваД. С.KaskaevаD. S.

к. м. н., доцент, руководитель отделения

кафедры поликлинической терапии и семейной медицины с курсом ПО; отделение общей врачебной практики

660022; ул. Партизана Железняка, 1; Красноярск

Researcher ID: S-8106-2016; Elibrary (Author ID): 543648; Author ID (Scopus):48662493200

Candidate of Medical Science, Associate Professor, Head of the Department

Department Polyclinic Therapy with Course of Postgraduate Education; Department of General Medical Practice

660022; 1 Partizan Zheleznyak St.; Krasnoyarsk

Researcher ID: S-8106-2016; Elibrary (Author ID): 543648; Author ID (Scopus):48662493200

dashakas.ru@mail.ruhttps://orcid.org/0000-0003-1575-633XЕвсюковА. А.EvsyukovA. A.

к. м. н., доцент

кафедра поликлинической терапии и семейной медицины с курсом ПО

660022; ул. Партизана Железняка, 1; Красноярск

Elibrary (Author ID): 543649; Author ID (Scopus): 6602687133

Candidate of Medical Science, Associate Professor

Department Polyclinic Therapy with Course of Postgraduate Education

660022; 1 Partizan Zheleznyak St.; Krasnoyarsk

Elibrary (Author ID): 543649; Author ID (Scopus): 6602687133

evsukovsasha@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Министерства здравоохранения Российской ФедерацииРоссияProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; V.M. Bekhterev National Research Medical Center for Psychiatry and NeurologyRussian Federation20250407202502140151Copyright © Петрова М.М., Шнайдер Н.А., Дмитренко Д.В., Петров А.В., Каскаева Д.С., Евсюков А.А., 20252025Петрова М.М., Шнайдер Н.А., Дмитренко Д.В., Петров А.В., Каскаева Д.С., Евсюков А.А.Petrova М.М., Shnayder N.A., Dmitrenko D.V., Petrov A.V., Kaskaevа D.S., Evsyukov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/444

   Острый инфаркт миокарда (ОИМ) является потенциальным жизнеугрожающим осложнением ишемической болезни сердца и занимает ведущее место в структуре смертности населения. В последние годы совершенствуются методы ранней диагностики ОИМ и коморбидных состояний, которые могут играть важную роль в персонализированном подходе к терапии и прогнозировании исходов и осложнений. Большой интерес российских и зарубежных исследователейвызывает проблема разработки и внедрения в реальную клиническую практику новых чувствительных и специфичных биохимических и молекулярных биомаркеров ОИМ.

   Цель настоящего тематического обзора состоит в поиске, обобщении и систематизации результатов фундаментальных и клинических исследований роли микроРНК как чувствительных и специфичных молекулярных биомаркеров ОИМ.

   Авторами проведен поиск публикаций в базах данных PubMed, Web of Science, Scopus, Cochrane Library, Springer, ClinicalKey, Oxford Press, e-Library с использованием ключевых слов и их комбинаций. Были проанализированы публикации за 2009–2024 гг., включая оригинальные клинические исследования ОИМ. В результате этого обзора показано, что циркулирующие miR-1, miR-133а, miR-208а могут рассматриваться как перспективные молекулярные биомаркеры ОИМ. Представленный краткий обзор свидетельствует о том, что ранняя диагностика ОИМ имеет перспективы развития за счет разработки и внедрения в реальную клиническую практику новых лабораторных тестов, включая исследование уровня циркулирующих микроРНК в крови с первых часов развития острого коронарного синдрома.

   Acute myocardial infarction (AMI) is a potential life-threatening complication of coronary heart disease and occupies a leading place in the mortality structure of the population. In recent years, methods of early diagnosis of AMI and comorbid conditions have been improved, which can play an important role in a personalized approach to therapy and prediction of outcomes and complications. The problem of developing and introducing new sensitive and specific biochemical and molecular biomarkers of AMI into real clinical practice is of great interest to Russian and foreign researchers.

   The purpose of this thematic review is to search, summarize and systematize the results of fundamental and clinical studies of the role of microRNAs as sensitive and specific molecular biomarkers of AMI.

   The authors conducted a search for publications in the databases PubMed, Web of Science, Scopus, Cochrane Library, Springer, ClinicalKey, Oxford Press, e-Library using keywords and their combinations. Publications from 2009–2024, including original clinical studies of AMI, were analyzed. As a result of this review, it was shown that circulating miR-1, miR-133a, and miR-208a can be considered promising molecular biomarkers of AMI. The presented brief review indicates that the early diagnosis of AMI has prospects for development due to the development and introduction into real clinical practice of new laboratory tests, including the study of the level of circulating microRNAs in the blood from the first hours of the development of acute coronary syndrome.

инфаркт миокардаострый коронарный синдромдиагностикабиомаркеркровьмикроРНКперсонализированная медицинаmyocardial infarctionacute coronary syndromediagnosisbiomarkerbloodmicroRNApersonalized medicineРабота выполнена в рамках государственного задания ФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» МЗ России (2023–2025) «Разработка персонализированного алгоритма диагностики сосудистой умеренной когнитивной дисфункции на фоне перенесенного острого инфаркта миокарда на основе новых генетических и биохимических биомаркеров», № 123022800057-6The work was carried out as part of the state assignment of the Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky of the Ministry of Health of the Russian Federation (2023–2025). 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The authors declare that there are no conflicts of interest present.