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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zabmedvestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Забайкальский медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Transbaikalian Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">1998-6173</issn><publisher><publisher-name>Читинская государственная медицинская академия</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52485/19986173_2025_3_40</article-id><article-id custom-type="elpub" pub-id-type="custom">zabmedvestnik-396</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>ОСТРОЕ ПОВРЕЖДЕНИЕ ПОЧЕК У ПАЦИЕНТОВ С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ С ПОДЪЕМОМ СЕГМЕНТА ST И СОПУТСТВУЮЩИМ МЕТАБОЛИЧЕСКИМ СИНДРОМОМ ПРИ ФАРМАКОИНВАЗИВНОЙ СТРАТЕГИИ</article-title><trans-title-group xml:lang="en"><trans-title>ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE CORONARY SYNDROME WITH ST-SEGMENT ELEVATION AND CONCOMITANT METABOLIC SYNDROME UNDER PHARMACOINVASIVE STRATEGY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростелев</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Korostelev</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коростелев Александр Сергеевич, к.м.н., доцент кафедры анестезиологии, реаниматологии с курсом скорой медицинской помощи, врач анестезиолог-реаниматолог отделения анестезиологии, реанимации и интенсивной терапии</p><p>677000, Республика Саха (Якутия), г. Якутск, ул. Белинского, 58</p></bio><bio xml:lang="en"><p>Korostelev A.S., Сandidate of Medical Sciences, Associate Professor of the Department of Anesthesiology, Resuscitation and Intensive Care, Anesthesiologist-resuscitator of the Department of Anesthesiology, Resuscitation and Intensive Care</p><p>4 Sergelyakhskoe shosse St., Yakutsk, Sakha Republic (Yakutia), 677001</p><p>58 Belinskogo St., Yakutsk, Sakha Republic (Yakutia), 677001</p></bio><email xlink:type="simple">bezbazaroff@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапов</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapov</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Потапов Александр Филиппович, д.м.н., профессор кафедры Анестезиологии, реаниматологии и интенсивной терапии с курсом скорой медицинской помощи</p><p>677000, Республика Саха (Якутия), г. Якутск, ул. Белинского, 58</p></bio><bio xml:lang="en"><p>Potapov, A.F., Doctor of Medical Sciences, Professor of the Department of Anesthesiology, Reanimation and Intensive Care with a course in Emergency Medical Care</p><p>58 Belinskogo St., Yakutsk, Sakha Republic (Yakutia), 677001</p></bio><email xlink:type="simple">potapov-paf@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Альбина Аммосовна, д.м.н., заведующая. кафедрой Анестезиологии, реаниматологии и интенсивной терапии с курсом скорой медицинской помощи</p><p>677000, Республика Саха (Якутия), г. Якутск, ул. Белинского, 58</p></bio><bio xml:lang="en"><p>Ivanova A.A., Doctor of Medical Sciences, Head of the Department of Anesthesiology, Reanimation and Intensive Care with a course in Emergency Medical Care</p><p>58 Belinskogo St., Yakutsk, Sakha Republic (Yakutia), 677001</p></bio><email xlink:type="simple">iaa_60@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Худайназарова</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khudainazarova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Худайназарова Ксения Адихамжоновна, аспирант кафедры внутренних болезней и общеврачебной практики (семейная медицина)</p><p>677000, Республика Саха (Якутия), г. Якутск, ул. Белинского, 58</p></bio><bio xml:lang="en"><p>Khudainazarova K.A., postgraduate student of the Department of Internal Diseases and General Practice (Family Medicine)</p><p>58 Belinskogo St., Yakutsk, Sakha Republic (Yakutia), 677001</p></bio><email xlink:type="simple">kseniiakh@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Булатов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bulatov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Булатов Алквиад Валентинович, к.м.н., директор Клинического центра</p><p>677001, Республика Саха (Якутия), г. Якутск, ул. Сергеляхское ш., 4</p></bio><bio xml:lang="en"><p>Bulatov A.V., Сandidate of Medical Sciences, Director of the Clinical Center</p><p>4 Sergelyakhskoe shosse St., Yakutsk, Sakha Republic (Yakutia), 677001</p></bio><email xlink:type="simple">alkviad06@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анисимов</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Anisimov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анисимов Сергей Степанович, заведующий детской кардиореанимацией Педиатрического центра</p><p>677000, Республика Саха (Якутия), г. Якутск, ул. Белинского, 58</p></bio><bio xml:lang="en"><p>Anisimov S.S., Head of the Children’s Cardiac Intensive Care Unit, Pediatric Center</p><p>4 Sergelyakhskoe shosse St., Yakutsk, Sakha Republic (Yakutia), 677001</p></bio><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sakha Republic’s Hospital No. 1 – M. E. Nikolaev National Center of Medicine; M. K. Ammosov North-Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M. K. Ammosov North-Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M. K. Ammosov North-Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГАУ Республики Саха (Якутия) «Республиканская больница № 1 – Национальный центр медицины им. М.Е. Николаева»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sakha Republic’s Hospital No. 1 – M. E. Nikolaev National Center of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sakha Republic’s Hospital No. 1 – M. E. Nikolaev National Center of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>02</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>40</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коростелев А.С., Потапов А.Ф., Иванова А.А., Худайназарова К.А., Булатов А.В., Анисимов С.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Коростелев А.С., Потапов А.Ф., Иванова А.А., Худайназарова К.А., Булатов А.В., Анисимов С.С.</copyright-holder><copyright-holder xml:lang="en">Korostelev A.S., Potapov A.F., Ivanova A.A., Khudainazarova A.V., Bulatov A.A., Anisimov S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zabmedvestnik.ru/jour/article/view/396">https://www.zabmedvestnik.ru/jour/article/view/396</self-uri><abstract><p>Цель исследования – проанализировать частоту и факторы риска острого повреждения почек (ОПП) у пациентов с острым коронарным синдромом с подъемом сегмента ST (ОКСпST) и сопутствующим метаболическим синдромом (МС) на фоне фармакоинвазивной стратегии лечения.Материал и методы. Для исследования было отобрано 78 пациентов, которые были разделены на 2 группы: 1 группа – пациенты с ОКСпST и сопутствующим МС (n = 36); 2 группа – больные с ОКСпST без МС (n = 42).Результаты исследования. По результатам исследования двух групп пациентов с ОКСпST установлены статистически достоверные различия по ряду показателей. Так, имелись различия в исходных показателях индекса массы тела (ИМТ) (p = 0,001) и уровня содержания общего холестерина (ОХС) (р &lt; 0,001), триглицеридов (ТГ) (р = 0,007), индекса триглицерид-глюкозы (ИТГ) (р &lt; 0,001), уровня креатинина: в первые сутки (р &lt; 0,006), на вторые и третьи сутки (p &lt; 0,001). Среднее значение скорости клубочковой фильтрации (СКФ) на вторые сутки в 1-й группе составило 66,7 ± 12,2, во 2-й группе – 57,3,2 ± 8,7 мл/мин/1,73м2 (p &lt; 0,001). Признаки ОПП в 1-й группе наблюдались у 8 (22,2%) больных, во 2-й группе – у 2 (4,8%) больных. Наряду с ОПП, у больных 1-й группы чаще встречались другие осложнения: нарушения ритма сердца (р &lt; 0,04) и отек легких (р &lt; 0,034). Также установлены достоверные различия по срокам лечения пациентов – больные 1-й группы дольше находились в условиях отделения анестезиологии, реанимации и интенсивной терапии (ОАРИТ) (р = 0,042) и в стационаре (р = 0,035).Заключение. У пациентов с ОКСпST и сопутствующим МС признаки ОПП встречались в 5,7 раза чаще, чем у больных без МС. По результатам исследования были выявлены следующие факторы, ассоциировавшиеся с развитием ОПП, способствующие развитию ОПП: высокий ИМТ (р&lt;0,001), повышение в крови ОХС (р = 0,01), ТГ (р = 0,007), ИТГ (р = 0,036)</p></abstract><trans-abstract xml:lang="en"><p>The aim of the study was to analyze the frequency and risk factors of acute kidney injury (AKI) in patients with ST-segment elevation acute coronary syndrome (STE-ACS) and concomitant metabolic syndrome (MS) under the pharmacoinvasive treatment strategy.Material and Methods. The study covered 78 patients divided into two groups: group 1 – STE-ACS patients with concomitant MS (n = 36); group 2 – STE-ACS patients without MS (n = 42).Results. The study established statistically valid differences between the two groups of STE-ACS patients by a number of indicators. In particular, there were differences in baseline values of the body mass index (BMI) (p = 0,001) and total cholesterol concentration (TC) (р &lt; 0,001), triglycerides (TG) (р = 0,007), triglycerideglucose index (TyG) (р &lt; 0,001), and the creatinine level: on day 1 (р &lt; 0,006), on days 2 and 3 (p &lt; 0,001). On day 2, the glomerular filtration rate (GFR) averaged in group 1 to 66,7 ± 12,2, and in group 2 – to 57,3 ± 8,7 ml/min/1,73m2 (p &lt; 0,001). AKI signs were observed in group 1 in 8 (22,2%) patients, in group 2 – in 2 (4,8%) patients. Along with AKI, the group 1 patients experienced other complications more frequently: cardiac rhythm disorder (р &lt; 0,04) and pulmonary edema (р &lt; 0,034). There were also established valid differences in the treatment duration: the group 1 patients stayed longer in the intensive care unit (ICU) (р = 0,042) and hospital (р = 0,035).Conclusion. The STE-ACS patients with concomitant MS demonstrated signs of AKI 5,7 times more often than the patients without MS. The study revealed the following factors associated with the AKI development: high BMI (р &lt; 0,001), increased TC in blood (р = 0,01), TG (р = 0,007), TyG (р = 0,036).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром с подъемом сегмента ST</kwd><kwd>метаболический синдром</kwd><kwd>осложнения</kwd><kwd>острое повреждение почек</kwd><kwd>факторы риска</kwd><kwd>скорость клубочковой фильтрации</kwd><kwd>триглицеридемия</kwd><kwd>фармакоинвазивная стратегия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ST-segment elevation acute coronary syndrome</kwd><kwd>metabolic syndrome</kwd><kwd>acute kidney injury</kwd><kwd>triglyceridemia</kwd><kwd>pharmacoinvasive strategy.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алекян Б. 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