zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2024_4_126zabmedvestnik-361Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSРОЛЬ МИОКИНОВ В УЛУЧШЕНИИ КОГНИТИВНЫХ ФУНКЦИЙTHE ROLE OF MYOKINES IN IMPROVING COGNITIVE FUNCTIONhttps://orcid.org/0000-0002-1796-2711ПетроваА. И.PetrovaA. I.

Петрова  Анжелика  Игоревна,  к.м.н.,  ассистент  кафедры  педиатрии

AuthorID: 963027, Scopus AuthorID: 57201847102

672000, г. Чита, ул. Горького, 39а

Petrova A.I., Candidate of Medical Sciences, assistant of the Department of Pediatrics

AuthorID: 963027, Scopus AuthorID: 57201847102

39а Gorky St., Chita, Russia, 672000

anzhelika_petrova_1992@mail.ruhttps://orcid.org/0000-0001-9918-4417МарковскийА. В.MarkovskiyA. V.

Марковский Александр Викторович, к.м.н., ассистент кафедры патологической физиологии

AuthorID: 824262, Scopus AuthorID: 57454161000

672000, г. Чита, ул. Горького, 39а

Markovskiy A.V., Candidate of Medical Sciences, assistant of the Department of Pathological Physiology

AuthorID: 824262, Scopus AuthorID: 57454161000

39а Gorky St., Chita, Russia, 672000

sorcerer-asy@mail.ruhttps://orcid.org/0000-0002-9670-9211ПотаповаН. Л.PotapovaN. I.

Потапова Наталья Леонидовна, д.м.н., доцент, заведующая кафедрой поликлинической педиатрии с курсом медицинской реабилитации

AuthorID: 639640, Scopus AuthorID: 57216661611

672000, г. Чита, ул. Горького, 39а

Potapova N.L., Doctor of Medical Sciences, docent, Head of the Department of Polyclinic Pediatrics with a course of medical rehabilitation

AuthorID: 639640, Scopus AuthorID: 57216661611

39а Gorky St., Chita, Russia, 672000

nataliapotap@yandex.ruhttps://orcid.org/0000-0002-0740-1718МизерницкийЮ. Л.MizernitskiyYu I.

Мизерницкий Юрий Леонидович, д.м.н., профессор, заслуженный работник здравоохранения Российской Федерации, заведующий отделом хронических, воспалительных и аллергических болезней легких Научно-исследовательского клинического института педиатрии и детской хирургии им. академика Ю.Е. Вельтищева, профессор кафедры инновационной педиатрии и детской хирургии Института непрерывного образования и профессионального развития ФГАОУ ВО РНИМУ им. Н.И.Пирогова

AuthorID: 383252, Scopus AuthorID: 56175636700

125412, г. Москва, ул. Талдомская, д. 2

Mizernitskiy Yu.L., Doctor of Medical Sciences, Professor, Head of the Department of Chronic, Inflammatory and Allergic Diseases lung diseases of Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery and Professor of the Department of Innovative Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University

AuthorID: 963027, Scopus AuthorID: 57201847102

2, Taldomskaya St., Moscow, Russia, 125412

yulmiz@mail.ruФГБОУ ВО «Читинская государственная медицинская академия» Министерства здравоохранения РФРоссияChita state medical academyRussian FederationНаучно-исследовательский клинический институт педиатрии и детской хирургии им. академика Ю.Е. Вельтищева ФГАОУ ВО РНИМУ им. Н.И. Пирогова Министерства здравоохранения РФРоссияVeltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical UniversityRussian Federation20242502202504126132Copyright © Петрова А.И., Марковский А.В., Потапова Н.Л., Мизерницкий Ю.Л., 20252025Петрова А.И., Марковский А.В., Потапова Н.Л., Мизерницкий Ю.Л.Petrova A.I., Markovskiy A.V., Potapova N.I., Mizernitskiy Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/361

За последние пару десятилетий стало очевидным, что скелетные мышцы работают как эндокринный орган, который может вырабатывать и секретировать миокины, оказывающие свое действие эндокринным, паракринным или аутокринным образом. Современные исследования показывают, что физические усилия индуцируют синтез молекул, участвующих в передаче сигналов между клетками скелетной мускулатуры и другими органами, в частности головным мозгом, жировой тканью, органами желудочно-кишечного тракта, а также клетками кожи и сосудов. В данном обзоре рассмотрены миокины, которые обусловливают связь с мозгом, нейропротекцию в ответ на физические нагрузки и связанные с ними процессы. В отличие от защитных миокинов, индуцируемых физической нагрузкой, и связанных с ними сигнальных путей, гиподинамия и истощение мышц могут нарушать экспрессию и секрецию миокинов и, в свою очередь, нарушать функцию центральной нервной системы. Предполагается, что адаптация передачи сигналов от мышц к головному мозгу путем модуляции миокинов поможет бороться с возрастной нейродегенерацией и заболеваниями мозга, на которые влияют системные сигналы.

Over the past couple of decades, it has become apparent that skeletal muscles work as an endocrine organ that can produce and secrete myokines that exert their effects in an endocrine, paracrine, or autocrine manner. Modern research shows that physical exertion induces the synthesis of molecules involved in the transmission of signals between skeletal muscle cells and other organs, in particular the brain, adipose tissue, organs of the gastrointestinal tract, as well as skin and vascular cells. This review examines the myokines that cause communication with the brain, neuroprotection in response to physical activity and related processes. Unlike exercise-induced protective myokines and related signaling pathways, physical inactivity and muscle wasting can disrupt the expression and secretion of myokines and, in turn, disrupt the function of the central nervous system. It is assumed that adapting the transmission of signals from muscles to the brain by modulating myokines will help combat age-related neurodegeneration and brain diseases affected by systemic signals.

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The authors declare that there are no conflicts of interest present.