zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2025_1_154zabmedvestnik-324Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSБиомаркеры сердечной недостаточности у пациентов с сахарным диабетом 2 типа: клинические сопоставления и влияние сахароснижающей терапииBiomarkers of heart failure in patients with type 2 diabetes mellitus: clinical comparisons and impact of hypoglycemic therapyhttps://orcid.org/0000-0001-8317-7765ДрукИ. В.DrukI. V.

Друк Инна Викторовна - д.м.н., доцент, заведующий кафедрой внутренних болезней и семейной медицины ДПО.

644099, Омск, ул. Ленина, 12; 644024, Омск, ул. Лермонтова, д. 41

Inna V. Druk - Doctor of Medical Sciences, Associate Professor, Head of the Department of Internal Medicine and Family Medicine.

12 Lenin St., Omsk, 644099; 41 Lermontov St., Omsk, 644024

drukinna@yandex.ruhttps://orcid.org/0000-0001-5852-2782СафроноваС. С.SafronovaS. S.

Сафронова Светлана Сергеевна - ассистент кафедры внутренних болезней и семейной медицины ДПО.

644099, Омск, ул. Ленина, 12; 644024, Омск, ул. Лермонтова, д. 41

Svetlana S. Safronova - Assistant of the Department of Internal Medicine and Family Medicine.

12 Lenin St., Omsk, 644099; 41 Lermontov St., Omsk, 644024

safronova.sv77@gmail.comhttps://orcid.org/0000-0001-8047-5521КоренноваО. Ю.KorennovaO. Yu.

Кореннова Ольга Юрьевна - д.м.н., профессор, профессор кафедры внутренних болезней и семейной медицины ДПО.

644099, Омск, ул. Ленина, 12; 644024, Омск, ул. Лермонтова, д. 41

Olga Yu. Korennova - Doctor of Medical Sciences, Professor, Professor of the Department of Internal Medicine and Family Medicine.

12 Lenin St., Omsk, 644099; 41 Lermontov St., Omsk, 644024

korennova@mail.ruhttps://orcid.org/0009-0003-3721-4379КанунниковаО. И.KanunnikovaO. I.

Канунникова Олеся Игорьевна - доцент кафедры внутренних болезней и семейной медицины ДПО.

644099, Омск, ул. Ленина, 12; 644024, Омск, ул. Лермонтова, д. 41

Olesya I. Kanunnikova - Associate Professor of the Department of Internal Medicine and Family Medicine.

12 Lenin St., Omsk, 644099; 41 Lermontov St., Omsk, 644024

lesia.tch@yandex.ruКазаченкоА. С.KazachenkoA. S.

Казаченко Анна Сергеевна - студентка 6 курса лечебного факультета.

644099, Омск, ул. Ленина, 12; 644024, Омск, ул. Лермонтова, д. 41

Anna S. Kazachenko - 6th-year student of the Faculty of Medicine.

12 Lenin St., Omsk, 644099; 41 Lermontov St., Omsk, 644024

lzubri-a@mail.ruФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения РФ; БУЗОО «Городской клинический кардиологический диспансер»РоссияOmsk State Medical University, Ministry of Health of the Russian Federation; City Clinical Cardiological DispensaryRussian Federation20250805202501154170Copyright © Друк И.В., Сафронова С.С., Кореннова О.Ю., Канунникова О.И., Казаченко А.С., 20252025Друк И.В., Сафронова С.С., Кореннова О.Ю., Канунникова О.И., Казаченко А.С.Druk I.V., Safronova S.S., Korennova O.Y., Kanunnikova O.I., Kazachenko A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/324

Основной причиной повышенной смертности пациентов с сахарным диабетом 2 типа (СД2) является сердечная недостаточность (СН). СН приводит к увеличению числа госпитализаций, ухудшению качества жизни и прогноза. Поскольку заболеваемость СН при СД2 постоянно увеличивается, возрос интерес к оптимальным диагностическим и прогностическим алгоритмам с использованием панели циркулирующих биомаркеров для обеспечения своевременной диагностики, улучшения лечения заболевания и прогноза пациентов. Так как число новых биомаркеров СН быстро растет, в этом обзоре изложены наиболее перспективные и доступные биомаркеры, связанные с фиброзом, – ключевым патофизиологическим механизмом СН, описана их полезность для диагностики, стратификации риска и скрининга СН при СД2, а также существующие ограничения.

The main cause of increased mortality in patients with type 2 diabetes mellitus (DM2) is heart failure (HF). HF leads to an increase in the number of hospitalizations, a deterioration in the quality of life and prognosis. As the incidence of HF in DM2 is constantly increasing, there is increased interest in optimal diagnostic and prognostic algorithms using a panel of circulating biomarkers to ensure timely diagnosis, improve disease treatment and patient prognosis. As the number of new HF biomarkers is growing rapidly, this review outlines the most promising and accessible biomarkers associated with fibrosis, a key pathophysiological mechanism of HF, and describes their usefulness for the diagnosis, risk stratification, and screening of HF in DM2, as well as existing limitations.

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The authors declare that there are no conflicts of interest present.