zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2025_1_195zabmedvestnik-311Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSГормональная регуляция нейрогенезаHormonal regulation of neurogenesishttps://orcid.org/0000-0001-7544-3779ТепляшинаЕ. А.TeplyashinaE. A.

Тепляшина Елена Анатольевна - канд. биол. наук, доцент, доцент кафедры биологической химии с курсом медицинской, фармацевтической и токсикологической химии, старший научный сотрудник НИИ молекулярной медицины и патобиохимии.

660022, Красноярск, ул. Партизана Железняка, 1

Researcher ID AAN-8547-2020; Author ID РИНЦ 96478; Author ID Scopus 56880351500

Elena A. Teplyashina - Candidate of Biological Sciences, Associate Professor, Associate Professor of the Department of Chemistry with a course in Medical, Pharmaceutical and Toxicological Chemistry, Senior Researcher at the Research Institute of Molecular Medicine and Pathobiochemistry.

1 Partizan Zheleznyak St., Krasnoyarsk, 660022

Researcher ID AAN-8547-2020; Author ID РИНЦ 96478; Author ID Scopus 56880351500

elenateplyashina@mail.ruhttps://orcid.org/0000-0002-0033-3804МалиновскаяН. А.MalinovskayaN. A.

Малиновская Наталия Александровна - д.м.н., заведующий кафедрой биологической химии с курсом медицинской, фармацевтической и токсикологической химии, старший научный сотрудник НИИ молекулярной медицины и патобиохимии.

660022, Красноярск, ул. Партизана Железняка, 1

Researcher ID AAN-4918-2020; Author ID РИНЦ 603088; Author ID Scopus 16175595000

Natalia A Malinovskaya - Doctor of Medical Sciences, Head of the Department of Chemistry with a course in Medical, Pharmaceutical and Toxicological Chemistry, Senior Researcher at the Research Institute of Molecular Medicine and Pathobiochemistry.

1 Partizan Zheleznyak St., Krasnoyarsk, 660022

Researcher ID AAN-4918-2020; Author ID РИНЦ 603088; Author ID Scopus 16175595000

malinovskaya-na@mail.ruhttps://orcid.org/0000-0002-1380-0280Ендржеевская-ШурыгинаВ. Ю.Endrzheevskaya-ShuryginaV. Yu.

Ендржеевская-Шурыгина Виктория Юлиановна - канд. хим. наук, доцент кафедры биологической химии с курсом медицинской, фармацевтической и токсикологической химии.

660022, Красноярск, ул. Партизана Железняка, 1

ResearcherID AAN-5687-2020; Author ID РИНЦ 701303; Author ID Scopus 57201744515

Victoria Yu. Endrzheevskaya-Shurygina - Candidate of Chemical Sciences, Associate Professor of the Department of Chemistry with a course in Medical, Pharmaceutical and Toxicological Chemistry.

1 Partizan Zheleznyak St., Krasnoyarsk, 660022

ResearcherID AAN-5687-2020; Author ID РИНЦ 701303; Author ID Scopus 57201744515

9135145077@mail.ruФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого», Министерства здравоохранения РФРоссияProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation20250805202501195207Copyright © Тепляшина Е.А., Малиновская Н.А., Ендржеевская-Шурыгина В.Ю., 20252025Тепляшина Е.А., Малиновская Н.А., Ендржеевская-Шурыгина В.Ю.Teplyashina E.A., Malinovskaya N.A., Endrzheevskaya-Shurygina V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/311

Ключевым процессом для изучения нейропластичности выступает нейрогенез и участие в нём гормонов. Цель настоящего обзора состоит в анализе новейших данных, полученных исследователями в этой области, и формировании общего представления о молекулярных механизмах действия гормонов на этапы нейрогенеза. Изучена литература, включающая научные отечественные и зарубежные публикации, которые были подготовлены преимущественно за последние пять лет.

Методами исследования выступали анализ первоисточников и научных результатов, полученных другими авторами. Использование сравнительного анализа позволило исследовать и сопоставить виды действия гормонов в зависимости от места их синтеза. Применение системно-структурного метода позволило сформировать авторскую схему, отображающую влияние гормонов на нейрогенез.

В обзоре рассматривается влияние гормонов на нейрогенез. Установлено, что снижение концентрации гормонов или нарушение их метаболизма может выступать причиной развития патологических состояний. Выявлено сходство нейронных и сосудистых сетей в механизмах их роста и развития.

Сформулирован вывод о необходимости изучения механизмов взаимосвязи нейрогенеза и ангиогенеза с целью выявления новых молекул, регулирующих активность пронейрогенных или проангиогенных клеток.

The key process for studying neuroplasticity is neurogenesis and the participation of hormones in it. The purpose of this review is to analyze the latest data obtained by researchers in this field and to form a general understanding of the molecular mechanisms of the action of hormones on the stages of neurogenesis. The literature was studied, including scientific domestic and foreign publications that were prepared mainly over the past five years.

The research methods were the analysis of primary sources and scientific results obtained by other authors. The use of comparative analysis made it possible to study and compare the types of action of hormones depending on the place of their synthesis. The use of the systemic-structural method made it possible to formulate the author’s diagram reflecting the influence of hormones on neurogenesis.

The review examines the influence of hormones on neurogenesis. It has been established that a decrease in the concentration of hormones or disruption of their metabolism can cause the development of pathological conditions. The similarities between neural and vascular networks in the mechanisms of their growth and development have been revealed.

The conclusion is formulated about the need to study the mechanisms of the relationship between neurogenesis and angiogenesis in order to identify new molecules that regulate the activity of proneurogenic or proangiogenic cells.

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The authors declare that there are no conflicts of interest present.