zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2024_3_112zabmedvestnik-252Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSНАРУШЕНИЕ ГЕМОСТАЗА В ПАТОГЕНЕЗЕ ИШЕМИЧЕСКОГО ИНСУЛЬТАDISRUPTION OF HEMOSTASIS IN THE PATHOGENESIS OF ISCHEMIC STROKEhttps://orcid.org/0000-0002-0975-2351ЦыбиковН. Н.TsybikovN. N.

Цыбиков Намжил Нанзатович, д.м.н., профессор, заведующий кафедрой патофизиологии

672000, г. Чита, ул. Горького, 39а

MD, Professor, Head of the Department of Pathophysiology

39a Gorky St., Chita, 672000

thybikov@mail.ruhttps://orcid.org/0000-0002-0724-0352ФефеловаЕ. В.FefelovaE. V.

Фефелова Елена Викторовна, д.м.н., доцент, профессор кафедры патофизиологии

672000, г. Чита, ул. Горького, 39а

MD, Professor, Department of Pathophysiology

39a Gorky St., Chita, 672000

fefelova.elena@mail.ruhttps://orcid.org/0000-0003-3161-1835БутинЕ. В.ButinE. V.

Бутин Евгений Васильевич, врач нейрохирург

672000, г. Чита, ул. Горького, 39а

Neurosurgeon

39a Gorky St., Chita, 672000

butin.z@mail.ruЦыдыповаА. Э.TsydypovaA. E.

Цыдыпова Аяна Эрдэниевна, студентка 3 курса стоматологического факультета

672000, г. Чита, ул. Горького, 39а

3rd year student

39a Gorky St., Chita, 672000

swelstorm@gmail.comФедеральное государственное бюджетное образовательное учреждение высшего образования «Читинская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Chita State Medical Academy”, Ministry of Health of the Russian FederationRussian Federation20241811202403112119Copyright © Цыбиков Н.Н., Фефелова Е.В., Бутин Е.В., Цыдыпова А.Э., 20242024Цыбиков Н.Н., Фефелова Е.В., Бутин Е.В., Цыдыпова А.Э.Tsybikov N.N., Fefelova E.V., Butin E.V., Tsydypova A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/252

В обзорной статье представлена актуальная информация о патогенетических особенностях гемостаза при ишемическом инсульте головного мозга на основе анализа научных статей, индексируемых в базах данных PubMed и Web of Science. Ишемический инсульт – это внезапная неврологическая недостаточность, обусловленная острой фокальной церебральной ишемией, приводящей к инфаркту головного мозга. В научных кругах значительно меньше освещена роль нарушений гемостаза в патогенезе ишемического инсульта, а также недостаточно изучены динамика нарушений и ранние признаки активации свертывающей системы крови, в том числе развитие геморрагической трансформации и вторичного вазоспазма.

This review article presents current information on the pathogenetic features of hemostasis in cerebral ischemic stroke based on the analysis of scientific articles indexed in PubMed and Web of Science databases. Ischemic stroke is a sudden neurological failure due to acute focal cerebral ischemia leading to cerebral infarction. The role of hemostasis disorders in the pathogenesis of ischemic stroke has been much less publicized in scientific circles, and the dynamics of disorders and early signs of activation of the blood coagulation system, including the development of hemorrhagic transformation and secondary vasospasm, have not been sufficiently studied.

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The authors declare that there are no conflicts of interest present.