zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2023_2_173zabmedvestnik-181Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSМЕТАБОЛИТЫ КИНУРЕНИНОВОГО ПУТИ ОБМЕНА ТРИПТОФАНА В РАЗВИТИИ АНГИОПАТИЙ ПРИ САХАРНОМ ДИАБЕТЕKYNURENINE PATHWAY METABOLITES OF TRYPTOPHAN METABOLISM IN THE DEVELOPMENT OF ANGIOPATHIES DURING DIABETES MELLITUSФефеловаЕ. В.FefelovaE. V.

г. Чита, ул. Горького, 39а, 672000

Chita, Gorky str., 39A, 672000 

СаклаковаО. А.SaklakovaO. A.

 г. Чита, ул. Коханского, 7, 672038

Chita, Kokhansky Street, 7672038 

МаксименяМ. В.MaksimenyaM. V.

г. Чита, ул. Горького, 39а, 672000

Chita, Gorky str., 39A, 672000 

КоцюржинскаяН. Н.KotsyurzhinskayaN. N.

г. Чита, ул. Горького, 39а, 672000

Chita, Gorky str., 39A, 672000 

КараваеваТ. М.KaravaevaT. M.

г. Чита, ул. Горького, 39а, 672000

Chita, Gorky str., 39A, 672000 

ТерешковП. П.TereshkovP. P.

г. Чита, ул. Горького, 39а, 672000

Chita, Gorky str., 39A, 672000 

Федеральное государственное бюджетное образовательное учреждение высшего образования «Читинская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияChita State Medical AcademyRussian FederationГосударственное учреждение здравоохранения «Краевая клиническая больница»РоссияPublic Health Agency “Regional Clinical Hospital”Russian Federation20230508202402173189Copyright © Фефелова Е.В., Саклакова О.А., Максименя М.В., Коцюржинская Н.Н., Караваева Т.М., Терешков П.П., 20242024Фефелова Е.В., Саклакова О.А., Максименя М.В., Коцюржинская Н.Н., Караваева Т.М., Терешков П.П.Fefelova E.V., Saklakova O.A., Maksimenya M.V., Kotsyurzhinskaya N.N., Karavaeva T.M., Tereshkov P.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/181Цель исследования

Цель исследования. Обзор современных сведений об участии промежуточных продуктов кинуренинового пути в патогенезе осложнений СД, а именно ангиопатий.

Материалы и методы

Материалы и методы. Выполнен электронный поиск научной литературы в PubMed и Embase, опубликованной до марта 2023 года на предмет статей, в которых сообщалось об особенностях обмена триптофана (TRP), кинуренина (KYN), кинуреновой кислоты (KYNA), ксантуреновой кислоты (XA), антраниловой кислоты (AA) и хинолиновой кислоты (QA) в норме и при сахарном диабете (СД), особое внимание уделялось роли кинуренинов в развитии дисфункции эндотелия.

Результаты

Результаты. Описано влияние многих кинуренинов на углеводный обмен, свободнорадикальные процессы, иммунные реакции, раскрыта их роль в формировании некоторых патологий, в том числе таких, как метаболический синдром, сахарный диабет и его сосудистые осложнения.

Заключение

Заключение. Кинурениновый путь преобразования TRP выполняет несколько важных функций в организме, результаты исследований звеньев его течения постепенно выявляют сложные взаимоотношения между метаболическими нарушениями обмена триптофана, сахарным диабетом и сосудистыми осложнениями. Многие вопросы остаются неизученными, в представленном обзоре литературы намечены некоторые патогенетические взаимосвязи.

Objective

Objective. To review current data about the participation of kynurenine pathway’s intermediate products in the pathogenesis of complications of diabetes, namely angiopathy.

Materials and methods

Materials and methods. There was an electronic research of the scientific literature in PubMed and Embase published up to March 2023 for articles that reported on the features of the metabolism of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), xanthurenic acid (XA), anthranilic acid (AA) and QUINoline acid (QA) in normal state and during diabetes mellitus (DM). Special attention was paid to the role of kynurenines in the development of endothelial dysfunction.

Results

Results. A descriptive research of the variety of kynurenines’ influence on carbohydrate metabolism, free radical processes, immune responses is described, as well as their role in the formation of some pathologies, including metabolic syndrome, diabetes mellitus and its vascular complications, is presented.

Conclusion

Conclusion. The kynurenine pathway of TRP conversion performs several important functions in the body; the results of studies of its course features gradually reveal the complicated relationship between metabolic disorders of tryptophan metabolism, diabetes mellitus and vascular complications. Many issues remain unexplored; some pathogenetic relationships are outlined in currnet literature review.

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The authors declare that there are no conflicts of interest present.