zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2022_2_99zabmedvestnik-168Research ArticleНАУЧНЫЕ ОБЗОРЫ, ИЛЛЮСТРИРОВАННЫЕ КЛИНИЧЕСКИМ НАБЛЮДЕНИЕМSCIENTIFIC REVIEWS ILLUSTRATED WITH CLINICAL CASE STUDIESИДИОПАТИЧЕСКИЙ АУТОИММУННЫЙ ЭНЦЕФАЛИТ С АНТИТЕЛАМИ К NMDA-РЕЦЕПТОРАМIDIOPATHIC AUTOIMMUNE ENCEPHALITIS WITH ANTIBODIES TO NMDA RECEPTORSШиршовЮ. А.ShirshovYu. A.

672000, Чита, ул. Горького, 39а

39 A Gorkogo str., Chita, 672000

Ма-Ван-дэА. Ю.Ma-Van-deA. Yu.

672000, Чита, ул. Горького, 39а

39 A Gorkogo str., Chita, 672000

МаруеваН. А.MaruevaN. A.

672000, Чита, ул. Горького, 39а

39 A Gorkogo str., Chita, 672000

БалданшириеваА. Д.BaldanshirievaA. D.

672000, Чита, ул. Горького, 39а

39 A Gorkogo str., Chita, 672000

Федеральное государственное бюджетное образовательное учреждение высшего образования «Читинская государственная медицинская академия» Минздрава РоссииРоссияChita State Medical AcademyRussian Federation2022050820240299105Copyright © Ширшов Ю.А., Ма-Ван-дэ А.Ю., Маруева Н.А., Балданшириева А.Д., 20242024Ширшов Ю.А., Ма-Ван-дэ А.Ю., Маруева Н.А., Балданшириева А.Д.Shirshov Y.A., Ma-Van-de A.Y., Marueva N.A., Baldanshirieva A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/168

Идиопатический аутоиммунный энцефалит с антителами к NMDA-рецепторам (ЭА к NMDAр) – тяжёлое заболевание нервной системы, отличающееся разнообразием психоневрологической патологии, вовлечением нейромедиаторных систем. Из-за широкого распространения глутаматэргической системы в ЦНС, заболевание имеет тяжёлое течение, выраженную психотическую симптоматику с полиморфной неврологической патологией. Преобладание острого психоза в дебюте, разнообразная клиническая картина с низкой диагностической ценностью нейровизуализации (МРТ) обуславливает трудности в установлении диагноза и назначения ранней патогенетической терапии.

В статье описывается клинический случай ЭА к NMDAр у ребёнка, возникший подостро и проявившийся тяжёлыми психическими нарушениями с присоединением в дальнейшем неврологических расстройств. Учитывая выраженность психических расстройств у пациента в детском возрасте, редкость данной патологии, постановка диагноза сопровождалась определёнными трудностями.

Idiopathic autoimmune encephalitis with antibodies to NMDA receptors (EA to NMDAR) is a severe disease of the nervous system characterized by a variety of neuropsychiatric pathology and an involvement of neurotransmitter systems. Due to the wide distribution of the glutamatergic system in the central nervous system, the disease has a severe course, prominent psychotic symptoms with polymorphic neurological pathology. The predominance of acute psychosis at the onset, a diverse clinical picture with a low diagnostic value of neuroimaging (MRI) causes difficulties in establishing a diagnosis and prescribing early pathogenetic therapy.

The article describes a clinical case of EA to NMDAr in a child that arose subacutely and manifested itself as severe mental disorders with further neurological disorders. Given the severity of mental disorders in a patient in childhood age, the rarity of this pathology, the statement of the diagnosis was accompanied by certain difficulties.

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The authors declare that there are no conflicts of interest present.