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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zabmedvestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Забайкальский медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Transbaikalian Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">1998-6173</issn><publisher><publisher-name>Читинская государственная медицинская академия</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52485/19986173_2022_1_71</article-id><article-id custom-type="elpub" pub-id-type="custom">zabmedvestnik-140</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИЕ ОСОБЕННОСТИ ОСТРОГО ВИРУСНОГО БРОНХИОЛИТА   У ДЕТЕЙ С ПРЕДИКТОРАМИ ТЯЖЕСТИ</article-title><trans-title-group xml:lang="en"><trans-title>CLINICAL FEATURES OF ACUTE VIRAL BRONCHIOLITIS IN CHILDREN WITH  PREDICTORS OF SEVERITY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бочкарева</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Bochkareva</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>672000, г. Чита, ул. Горького, 39а</p></bio><bio xml:lang="en"><p>39a Gorky str., Chita, 672000</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мироманова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Miromanova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>672000, г. Чита, ул. Горького, 39а</p></bio><bio xml:lang="en"><p>39a Gorky str., Chita, 672000</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Читинская государственная медицинская академия Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chita State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>04</day><month>08</month><year>2024</year></pub-date><volume>0</volume><issue>1</issue><fpage>71</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бочкарева Л.С., Мироманова Н.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Бочкарева Л.С., Мироманова Н.А.</copyright-holder><copyright-holder xml:lang="en">Bochkareva L.S., Miromanova N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zabmedvestnik.ru/jour/article/view/140">https://www.zabmedvestnik.ru/jour/article/view/140</self-uri><abstract><sec><title>Цель  исследования</title><p>Цель  исследования. Изучить  клинические  особенности  острого  вирусного  бронхиолита  у госпитализированных детей, имеющих предикторы развития его тяжелого течения. </p><p>Материалы и методы исследования. Проведен ретроспективный анализ 124 медицинских карт детей первого года жизни с острым вирусным бронхиолитом, проходивших этап стационарного лечения с января 2013 по апрель 2019 гг. Анализируемые распределены в две группы: первая (n=34) с предикторами  тяжести  вирусного  бронхиолита,  вторая  (n=90)  без  факторов  риска  развития тяжелого заболевания. Оценивались количественные и качественные признаки в группах: развитие тяжелого бронхиолита, формирование осложнений, наличие дыхательной недостаточности и ее выраженность,  потребность  госпитализации  в  отделение  реанимации  и  кислородной  терапии, лабораторные маркеры бактериальной инфекции. </p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что у детей с предикторами тяжести, вирусный бронхиолит в 67,7% протекает в тяжелой форме, в 32,3% случаев развивается нетяжелое клиническое течение болезни. Независимо от наличия факторов риска, тяжесть течения бронхиолита определяет выраженность дыхательной недостаточности с преимущественной регистрацией тяжелых форм среди детей, имеющих  предикторы  тяжести.  Дети  с  факторами  риска  развития  тяжелого  бронхиолита требовали  частой  госпитализации  в  отделение  реанимации  (67,7%),  неинвазивной  кислородной терапии (94,1%), потребности в искусственной вентиляции легких в первые 6 часов госпитализации (20,6%) в случае развития заболевания, независимо от этиологического фактора бронхиолита. </p></sec><sec><title>Заключение</title><p>Заключение. Проведенный анализ подтвердил важность учета предикторов тяжести бронхиолита среди детей раннего возраста в связи со значительным риском развития тяжелого его течения, высокой  потребностью  госпитализации  в  отделение  реанимации,  развитием  дыхательной недостаточности,  требующей  кислородной  терапии.  Вместе  с  тем,  частота  формирования тяжелого  бронхиолита  среди  детей,  не  имеющих  традиционных  предикторов  тяжести заболевания, позволяет обосновывать поиск новых, в том числе генетических, маркеров различной степени тяжести течения вирусного бронхиолита у детей.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>The aim of the research</title><p>The aim of the research. To study the clinical features of acute viral bronchiolitis in hospitalized children with predictors of its severe course.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A retrospective analysis of 124 medical records of children in the first year of life with acute viral bronchiolitis who underwent the stage of inpatient treatment from January 2013 to April 2019 was carried out. The subjects were divided into two groups: the first (n=34) with predictors of the severity of viral bronchiolitis, the second (n=90) without risk factors for the development of a serious illness. The quantitative and qualitative signs in the groups were assessed: the development of severe bronchiolitis, the  formation  of  complications,  the  presence  of  respiratory  failure  and  its  severity,  the  need  for hospitalization in the intensive care unit and oxygen therapy, laboratory markers of bacterial infection.</p></sec><sec><title>Results</title><p>Results. It was found that in children with severity predictors, viral bronchiolitis in 67.7% proceeds in a severe form, in 32.3% of cases a mild clinical course of the disease develops. Regardless of the presence of risk factors, the severity of the course of bronchiolitis determines the severity of respiratory failure with the predominant registration of severe forms among children with predictors of severity. Children with risk factors for the development of severe bronchiolitis required frequent hospitalization in the intensive care unit (67.7%), non-invasive oxygen therapy (94.1%), the need for mechanical ventilation in the first 6 hours of hospitalization (20.6%) in case of the development of the disease, regardless of the etiological factor of bronchiolitis.</p></sec><sec><title>Conclusion</title><p>Conclusion. The analysis confirmed the importance of taking into account predictors of the severity of bronchiolitis among young children in connection with the significant risk of developing its severe course, the high need for hospitalization in the intensive care unit, and the development of respiratory failure requiring oxygen therapy. At the same time, the frequency of the formation of severe bronchiolitis among children who do not have traditional predictors of the severity of the disease makes it possible to justify the search for new, including genetic, markers of varying severity of the course of viral bronchiolitis in children.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхиолит</kwd><kwd>респираторно-синцитиальный вирус</kwd><kwd>предикторы тяжести</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bronchiolitis</kwd><kwd>respiratory syncytial virus</kwd><kwd>predictors of severity</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Геппе Н.А., Розинова Н.Н., Волков И.К., Мизерницкий Ю.Л. Классификация клинических форм бронхолегочных заболеваний у детей. 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