<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zabmedvestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Забайкальский медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Transbaikalian Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">1998-6173</issn><publisher><publisher-name>Читинская государственная медицинская академия</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52485/19986173_2023_1_165</article-id><article-id custom-type="elpub" pub-id-type="custom">zabmedvestnik-136</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS</subject></subj-group></article-categories><title-group><article-title>Роль эндотелиальной синтазы оксида азота в патогенезе эссенциальной артериальной гипертензии</article-title><trans-title-group xml:lang="en"><trans-title>The role of endothelial nitric oxide synthase in the pathogenesis of essential hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михно</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhno</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>672000; ул. Горького, 39А; Чита</p></bio><bio xml:lang="en"><p>672000; 39A, Gorky str.; Chita</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богомолова</surname><given-names>И. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogomolova</surname><given-names>I. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>672000; ул. Горького, 39А; Чита</p></bio><bio xml:lang="en"><p>672000; 39A, Gorky str.; Chita</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Читинская государственная медицинская академия» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chita Sate Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>04</day><month>08</month><year>2024</year></pub-date><volume>0</volume><issue>1</issue><fpage>165</fpage><lpage>172</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Михно В.А., Богомолова И.К., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Михно В.А., Богомолова И.К.</copyright-holder><copyright-holder xml:lang="en">Mikhno V.A., Bogomolova I.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zabmedvestnik.ru/jour/article/view/136">https://www.zabmedvestnik.ru/jour/article/view/136</self-uri><abstract><p>   Эссенциальная артериальная гипертензия − это сложное заболевание, определяемое взаимодействием генетических и внешнесредовых факторов. В обзоре приведены краткие сведения об оксиде азота, синтазе оксида азота. Представлены современные данные о роли эндотелиальной синтазы оксида азота в развитии артериальной гипертензии.</p></abstract><trans-abstract xml:lang="en"><p>   Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors. This review provides information on the nitric oxide, nitric oxide synthase. Current data on the role of endothelial nitric oxide synthase in the development of arterial hypertension are presented.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>оксид азота</kwd><kwd>синтаза оксида азота</kwd><kwd>эссенциальная артериальная гипертензия</kwd><kwd>первичная артериальная гипертензия</kwd><kwd>эндотелиальная дисфункция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nitric oxide</kwd><kwd>nitric oxide synthase</kwd><kwd>nitric oxide synthase</kwd><kwd>essential hypertension</kwd><kwd>primary hypertension</kwd><kwd>endothelial dysfunction</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело финансовой поддержки</funding-statement><funding-statement xml:lang="en">The study had no financial support</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васькина Е.А. Артериальная гипертензия: окислительный стресс и эндотелиальная дисфункция [диссертация … док. мед. наук]. Новосибирская государственная медицинская академия Министерства здравоохранения Российской Федерации. 2004.</mixed-citation><mixed-citation xml:lang="en">Vas'kina E.A. Arterial hypertension: oxidative stress and endothelial dysfunction [dissertation]. Novosibirsk. Novosibirsk State Medical University. 2004. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Veresh Z., Racz A., Lotz G., Koller A. ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway. Hypertension. 2008. 52(5). 960-966. DOI: 10.1161/HYPERTENSIONAHA.108.116731.</mixed-citation><mixed-citation xml:lang="en">Veresh Z., Racz A., Lotz G., Koller A. ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway. Hypertension. 2008. 52(5). 960-966. DOI: 10.1161/HYPERTENSIONAHA.108.116731.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ding J., Yu M., Jiang J., Luo Y., Zhang Q., Wang S., Yang F., Wang A., Wang L., Zhuang M., Wu S., Zhang Q., Xia Y., Lu D. Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via ATR Nox/ROS/PP2A Pathway. Front Physiol. 2020 Sep 11. a566410. DOI: 10.3389/fphys.2020.566410.</mixed-citation><mixed-citation xml:lang="en">Ding J., Yu M., Jiang J., Luo Y., Zhang Q., Wang S., Yang F., Wang A., Wang L., Zhuang M., Wu S., Zhang Q., Xia Y., Lu D. Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via ATR Nox/ROS/PP2A Pathway. Front Physiol. 2020 Sep 11. a566410. DOI: 10.3389/fphys.2020.566410.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Гзогян М.Н. Влияние длительных контролируемых велотренировок с α1-, β1-, β2–адреноблокадой и ингибицией АПФ на регресс сердечной недостаточности и эндотелиальной дисфункции у больных инфарктом миокарда [диссертация … канд. мед. наук]. Научно-исследовательский институт кардиологии Томского научного центра СО РАМН. 2005.</mixed-citation><mixed-citation xml:lang="en">Gzogjan M.N. The effect of long-term controlled cycling with α1-, β1–, β2-adrenoblockade and ACE inhibition on the regression of heart failure and endothelial dysfunction in patients with myocardial infarction [dissertation]. Tomsk NRMC Cardiology research institute. 2005. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Лермонтова Н.Ю. Клиническая и прогностическая ценность показателей эндотелиальной дисфункции и агрегации тромбоцитов у пациентов с нестабильной стенокардией [диссертация … канд. мед. наук]. Научно-исследовательский институт кардиологии Томского научного центра СО РАМН. 2005.</mixed-citation><mixed-citation xml:lang="en">Lermontova N.Ju. Clinical and prognostic value of indicators of endothelial dysfunction and aggregation of platelets in patients with acute ischemic disease of heart [dissertation]. Tomsk NRMC Cardiology research institute. 2005. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Попова А.А. Ранние маркёры дисфункции эндотелия у лиц молодого возраста с артериальной гипертонией [диссертация … канд. мед. наук]. Новосибирская государственная медицинская академия Министерства здравоохранения Российской Федерации. 2004.</mixed-citation><mixed-citation xml:lang="en">Popova A.A. Early markers of endothelial dysfunction in young people with arterial hypertension [dissertation]. Novosibirsk. Novosibirsk State Medical University. 2004. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Zhuo J.L., Mendelsohn F.A., Ohishi M. Perindopril alters vascular angiotensin-converting enzyme, AT(1) receptor, and nitric oxide synthase expression in patients with coronary heart disease. Hypertension. 2002 Feb. 39(2). 634-638. DOI: 10.1161/hy0202.103417.</mixed-citation><mixed-citation xml:lang="en">Zhuo J.L., Mendelsohn F.A., Ohishi M. Perindopril alters vascular angiotensin-converting enzyme, AT(1) receptor, and nitric oxide synthase expression in patients with coronary heart disease. Hypertension. 2002 Feb. 39(2). 634-638. DOI: 10.1161/hy0202.103417.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia V., Sessa W.C. Endothelial NOS: perspective and recent developments. Br J Pharmacol. 2019 Jan. 176(2). 189-196. DOI: 10.1111/bph.14522.</mixed-citation><mixed-citation xml:lang="en">Garcia V., Sessa W.C. Endothelial NOS: perspective and recent developments. Br J Pharmacol. 2019 Jan. 176(2). 189-196. DOI: 10.1111/bph.14522.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Daiber A., Xia N., Steven S., Oelze M., Hanf A., Kröller-Schön S., Münzel T., Li H. New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease. Int J Mol Sci. 2019 Jan. 20(1). 187. DOI: 10.3390/ijms20010187.</mixed-citation><mixed-citation xml:lang="en">Daiber A., Xia N., Steven S., Oelze M., Hanf A., Kröller-Schön S., Münzel T., Li H. New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease. Int J Mol Sci. 2019 Jan. 20(1). 187. DOI: 10.3390/ijms20010187.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Farah C., Michel L.Y.M., Balligand J.L. Nitric oxide signalling in cardiovascular health and disease. Nat Rev Cardiol. 2018 May. 15(5). 292-316. DOI: 10.1038/nrcardio.2017.224.</mixed-citation><mixed-citation xml:lang="en">Farah C., Michel L.Y.M., Balligand J.L. Nitric oxide signalling in cardiovascular health and disease. Nat Rev Cardiol. 2018 May. 15(5). 292-316. DOI: 10.1038/nrcardio.2017.224.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Suvorava T., Metry S., Pick S., Kojda G. Alterations in endothelial nitric oxide synthase activity and their relevance to blood pressure. Biochem Pharmacol. 2022 Nov. 205. 115256. DOI: 10.1016/j.bcp.2022.115256.</mixed-citation><mixed-citation xml:lang="en">Suvorava T., Metry S., Pick S., Kojda G. Alterations in endothelial nitric oxide synthase activity and their relevance to blood pressure. Biochem Pharmacol. 2022 Nov. 205. 115256. DOI: 10.1016/j.bcp.2022.115256.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pautz A., Li H., Kleinert H. Regulation of NOS expression in vascular diseases. Front Biosci (Landmark Ed). 2021 Apr. 26(5). 85-101. DOI 10.52586/4926.</mixed-citation><mixed-citation xml:lang="en">Pautz A., Li H., Kleinert H. Regulation of NOS expression in vascular diseases. Front Biosci (Landmark Ed). 2021 Apr. 26(5). 85-101. DOI: 10.52586/4926.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem J. 2001 Aug. 357(3). 593-615. DOI: 10.1042/0264-6021:3570593.</mixed-citation><mixed-citation xml:lang="en">Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem J. 2001 Aug. 357(3). 593-615. DOI: 10.1042/0264-6021:3570593.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kourosh-Arami M., Hosseini N., Mohsenzadegan M., Komaki A., Joghataei M.T. Neurophysiologic implications of neuronal nitric oxide synthase. Rev Neurosci. 2020 Aug. 31(6). 617-636. DOI: 10.1515/revneuro-2019-0111.</mixed-citation><mixed-citation xml:lang="en">Kourosh-Arami M., Hosseini N., Mohsenzadegan M., Komaki A., Joghataei M.T. Neurophysiologic implications of neuronal nitric oxide synthase. Rev Neurosci. 2020 Aug. 31(6). 617-636. DOI: 10.1515/revneuro-2019-0111.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tran N., Garcia T., Aniqa M., Ali S., Ally A., Nauli S.M. Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States. Am J Biomed Sci Res. 2022. 15(2). 153-177. DOI: 10.34297/AJBSR.2022.15.002087.</mixed-citation><mixed-citation xml:lang="en">Tran N., Garcia T., Aniqa M., Ali S., Ally A., Nauli S.M. Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States. Am J Biomed Sci Res. 2022. 15(2). 153-177. DOI: 10.34297/AJBSR.2022.15.002087.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ally A., Powell I., Ally M.M., Chaitoff K., Nauli S.M. Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states. Nitric Oxide. 2020 Sep. 102. 52-73. DOI: 10.1016/j.niox.2020.06.004.</mixed-citation><mixed-citation xml:lang="en">Ally A., Powell I., Ally M.M., Chaitoff K., Nauli S.M. Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states. Nitric Oxide. 2020 Sep. 102. 52-73. DOI: 10.1016/j.niox.2020.06.004.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang T., Guo D., Zheng W., Dai Q. Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats. Mol Med Rep. 2021 Jun. 23(6). 456. DOI: 10.3892/mmr.2021.12095.</mixed-citation><mixed-citation xml:lang="en">Zhang T., Guo D., Zheng W., Dai Q. Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats. Mol Med Rep. 2021 Jun. 23(6). 456. DOI: 10.3892/mmr.2021.12095.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Eid S.A., Hinder L.M., Zhang H., Eksi R., Nair V., Eddy S., Eichinger F., Park M., Saha J., Berthier C.C., Jagadish H.V., Guan Y., Pennathur S., Hur J., Kretzler M., Feldman E.L., Brosius F.C. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. FASEB J. 2021 May. 35(5). e21467. DOI: 10.1096/fj.202002387R.</mixed-citation><mixed-citation xml:lang="en">Eid S.A., Hinder L.M., Zhang H., Eksi R., Nair V., Eddy S., Eichinger F., Park M., Saha J., Berthier C.C., Jagadish H.V., Guan Y., Pennathur S., Hur J., Kretzler M., Feldman E.L., Brosius F.C. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. FASEB J. 2021 May. 35(5). e21467. DOI: 10.1096/fj.202002387R.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ninchoji T., Love D.T., Smith R.O., Hedlund M., Vestweber D., Sessa W.C., Claesson-Welsh L. eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. Elife. 2021 Apr. 10. e64944. DOI: 10.7554/eLife.64944.</mixed-citation><mixed-citation xml:lang="en">Ninchoji T., Love D.T., Smith R.O., Hedlund M., Vestweber D., Sessa W.C., Claesson-Welsh L. eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. Elife. 2021 Apr. 10. e64944. DOI: 10.7554/eLife.64944.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">García-Martín E., Navarro-Muñoz S., Rodriguez C., Serrador M., Alonso-Navarro H., Calleja M., Turpín-Fenoll L., Recio-Bermejo M., García-Ruiz R., Millán-Pascual J., Navacerrada F., Plaza-Nieto J.F., García-Albea E., Agúndez J.A.G., Jiménez-Jiménez F.J. Association between endothelial nitric oxide synthase (NOS3) rs2070744 and the risk for migraine. Pharmacogenomics J. 2020 Jun. 20(3). 426-432. DOI: 10.1038/s41397-019-0133-x.</mixed-citation><mixed-citation xml:lang="en">García-Martín E., Navarro-Muñoz S., Rodriguez C., Serrador M., Alonso-Navarro H., Calleja M., Turpín-Fenoll L., Recio-Bermejo M., García-Ruiz R., Millán-Pascual J., Navacerrada F., Plaza-Nieto J.F., García-Albea E., Agúndez J.A.G., Jiménez-Jiménez F.J. Association between endothelial nitric oxide synthase (NOS3) rs2070744 and the risk for migraine. Pharmacogenomics J. 2020 Jun. 20(3). 426-432. DOI: 10.1038/s41397-019-0133-x.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Modena M., Vecoli C., Caselli C., Todiere G., Poddighe R., Valente S., Bandini F., Natali A., Ghiadoni L., Clerico A., Vittorini S., Botto N., Andreassi M.G., Emdin M., Neglia D. Association of eNOS Glu298Asp polymorphism with cardiometabolic risk and inducible myocardial ischemia in patients with stable coronary artery disease. European Heart Journal. 2022. 43(2). DOI: 10.1093/eurheartj/ehac544.1112.</mixed-citation><mixed-citation xml:lang="en">Modena M., Vecoli C., Caselli C., Todiere G., Poddighe R., Valente S., Bandini F., Natali A., Ghiadoni L., Clerico A., Vittorini S., Botto N., Andreassi M.G., Emdin M., Neglia D. Association of eNOS Glu298Asp polymorphism with cardiometabolic risk and inducible myocardial ischemia in patients with stable coronary artery disease. European Heart Journal. 2022. 43(2). DOI: 10.1093/eurheartj/ehac544.1112.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021. 398(10304). 957-980. DOI: 10.1016/S0140-6736(21)01330-1.</mixed-citation><mixed-citation xml:lang="en">NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021. 398(10304). 957-980. DOI: 10.1016/S0140-6736(21)01330-1.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tsao C.W., Aday A.W., Almarzooq Z.I., et al. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Circulation. 2022. 145(8). 153-639. DOI: 10.1161/CIR.0000000000001052.</mixed-citation><mixed-citation xml:lang="en">Tsao C.W., Aday A.W., Almarzooq Z.I., et al. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Circulation. 2022. 145(8). 153-639. DOI: 10.1161/CIR.0000000000001052.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Заболеваемость населения по основным классам болезней в 2000 - 2021 гг. Федеральная служба государственной статистики Министерства экономического развития Российской Федерации. Режим доступа: https://rosstat.gov.ru/folder/13721.</mixed-citation><mixed-citation xml:lang="en">Morbidity of the population by the main classes of diseases in 2000-2021. The Federal State Statistics Service of the Ministry of Economic Development of the Russian Federation. Available from: https://rosstat.gov.ru/folder/13721. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Śladowska-Kozłowska J., Litwin M., Niemirska A., Wierzbicka A., Roszczynko M., Szperl M. Associations of the eNOS G894T gene polymorphism with target organ damage in children with newly diagnosed primary hypertension. Pediatr Nephrol. 2015 Dec. 30(12). 2189-2197. DOI: 10.1007/s00467-015-3164-9.</mixed-citation><mixed-citation xml:lang="en">Śladowska-Kozłowska J., Litwin M., Niemirska A., Wierzbicka A., Roszczynko M., Szperl M. Associations of the eNOS G894T gene polymorphism with target organ damage in children with newly diagnosed primary hypertension. Pediatr Nephrol. 2015 Dec. 30(12). 2189-2197. DOI: 10.1007/s00467-015-3164-9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Nassereddine S., Hassani Idrissi H., Habbal R., Abouelfath R., Korch F., Haraka M., Karkar A., Nadifi S. The polymorphism G894 T of endothelial nitric oxide synthase (eNOS) gene is associated with susceptibility to essential hypertension (EH) in Morocco. BMC Med Genet. 2018 Jul. 19(1). 127. DOI: 10.1186/s12881-018-0638-1.</mixed-citation><mixed-citation xml:lang="en">Nassereddine S., Hassani Idrissi H., Habbal R., Abouelfath R., Korch F., Haraka M., Karkar A., Nadifi S. The polymorphism G894 T of endothelial nitric oxide synthase (eNOS) gene is associated with susceptibility to essential hypertension (EH) in Morocco. BMC Med Genet. 2018 Jul. 19(1). 127. DOI: 10.1186/s12881-018-0638-1.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Abbasi H., Dastgheib S.A., Hadadan A., Karimi-Zarchi M., Javaheri A., Meibodi B., Zanbagh L., Tabatabaei R.S., Neamatzadeh H. Association of Endothelial Nitric Oxide Synthase 894G &gt; T Polymorphism with Preeclampsia Risk : A Systematic Review and Meta-Analysis based on 35 Studies. Fetal Pediatr Pathol. 2021 Oct. 40(5). 455-470. DOI: 10.1080/15513815.2019.1710880.</mixed-citation><mixed-citation xml:lang="en">Abbasi H., Dastgheib S.A., Hadadan A., Karimi-Zarchi M., Javaheri A., Meibodi B., Zanbagh L., Tabatabaei R.S., Neamatzadeh H. Association of Endothelial Nitric Oxide Synthase 894G &gt; T Polymorphism with Preeclampsia Risk : A Systematic Review and Meta-Analysis based on 35 Studies. Fetal Pediatr Pathol. 2021 Oct. 40(5). 455-470. DOI: 10.1080/15513815.2019.1710880.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Inácio A., Aguiar L., Bicho M., Freitas J., Faustino P., Matos A., Menezes Falcão L. Interplay between glycemia and the genetics of eNOS and ACE for the susceptibility to the onset and development of hypertension on the Portuguese population. Gene Reports. 2021. 22(1–2). DOI: 10.1016/j.genrep.2020.100975.</mixed-citation><mixed-citation xml:lang="en">Inácio A., Aguiar L., Bicho M., Freitas J., Faustino P., Matos A., Menezes Falcão L. Interplay between glycemia and the genetics of eNOS and ACE for the susceptibility to the onset and development of hypertension on the Portuguese population. Gene Reports. 2021. 22(1–2). DOI: 10.1016/j.genrep.2020.100975.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Shi J., Liu S., Guo Y., Liu S., Xu J., Pan L., Hu Y., Liu Y., Cheng Y. Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls. BMC Cardiovasc Disord. 2021 Aug. 21(1). 385. DOI: 10.1186/s12872-021-02192-2.</mixed-citation><mixed-citation xml:lang="en">Shi J., Liu S., Guo Y., Liu S., Xu J., Pan L., Hu Y., Liu Y., Cheng Y. Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls. BMC Cardiovasc Disord. 2021 Aug. 21(1). 385. DOI: 10.1186/s12872-021-02192-2.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Xu X., Ye W., Chen H., Liu M., Jiang W., Fang Z. Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension : a systematic review and meta-analysis. Journal of International Medical Research. 2021. 49(3). 1–14. DOI: 10.1177/0300060520979230.</mixed-citation><mixed-citation xml:lang="en">Xu X., Ye W., Chen H., Liu M., Jiang W., Fang Z. Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension : a systematic review and meta-analysis. Journal of International Medical Research. 2021. 49(3). 1–14. DOI: 10.1177/0300060520979230.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang S., Yang G., Zhou S., Zhang X., Peng C., Lu Q. Bisphenol A, S, and F exposure, ESR1/2, CAT, and eNOS genetic polymorphisms, and the risk of hypertension. Ecotoxicol Environ Saf. 2021 Aug. 224:112684. DOI: 10.1016/j.ecoenv.2021.112684.</mixed-citation><mixed-citation xml:lang="en">Jiang S., Yang G., Zhou S., Zhang X., Peng C., Lu Q. Bisphenol A, S, and F exposure, ESR1/2, CAT, and eNOS genetic polymorphisms, and the risk of hypertension. Ecotoxicol Environ Saf. 2021 Aug. 224:112684. DOI: 10.1016/j.ecoenv.2021.112684.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Chenou F., Albuquerque D.M., Leonardo D.P., Domingos I.F., Bezerra M.A.C., Araújo A.S., Blotta M.H.S.L., Costa F.F., Sonati M.F., Paula E.V., Santos M.N.N.. Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphisms and Markers of Hemolysis, Inflammation and Endothelial Dysfunction in Brazilian Sickle Cell Anemia Patients. Biochem Genet. 2020 Aug, 58(4). 580-594. DOI: 10.1007/s10528-020-09959-w.</mixed-citation><mixed-citation xml:lang="en">Chenou F., Albuquerque D.M., Leonardo D.P., Domingos I.F., Bezerra M.A.C., Araújo A.S., Blotta M.H.S.L., Costa F.F., Sonati M.F., Paula E.V., Santos M.N.N.. Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphisms and Markers of Hemolysis, Inflammation and Endothelial Dysfunction in Brazilian Sickle Cell Anemia Patients. Biochem Genet. 2020 Aug, 58(4). 580-594. DOI: 10.1007/s10528-020-09959-w.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J., Shi M., Wang N., Yi P., Sun L., Meng Q. TSH inhibits eNOS expression in HMEC-1 cells through the TSHR/PI3K/AKT signaling pathway. Ann Endocrinol (Paris). 2019 Nov. 80(5-6). 273-279. DOI: 10.1016/j.ando.2019.06.007.</mixed-citation><mixed-citation xml:lang="en">Chen J., Shi M., Wang N., Yi P., Sun L., Meng Q. TSH inhibits eNOS expression in HMEC-1 cells through the TSHR/PI3K/AKT signaling pathway. Ann Endocrinol (Paris). 2019 Nov. 80(5-6). 273-279. DOI: 10.1016/j.ando.2019.06.007.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Couto G.K., Paula S.M., Gomes-Santos I.L., Negrão C.E., Rossoni L.V. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. Am J Physiol Heart Circ Physiol. 2018 Apr. 314(4). H878-H887. DOI: 10.1152/ajpheart.00624.2017.</mixed-citation><mixed-citation xml:lang="en">Couto G.K., Paula S.M., Gomes-Santos I.L., Negrão C.E., Rossoni L.V. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. Am J Physiol Heart Circ Physiol. 2018 Apr. 314(4). H878-H887. DOI: 10.1152/ajpheart.00624.2017.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Marino F., Scalise M., Cianflone E., Salerno L., Cappetta D., Salerno N., De Angelis A., Torella D., Urbanek K.. Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology. Antioxidants (Basel). 2021 Jun. 10(7). 1002. DOI: 10.3390/antiox10071002.</mixed-citation><mixed-citation xml:lang="en">Marino F., Scalise M., Cianflone E., Salerno L., Cappetta D., Salerno N., De Angelis A., Torella D., Urbanek K.. Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology. Antioxidants (Basel). 2021 Jun. 10(7). 1002. DOI: 10.3390/antiox10071002.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Khalaf D., Krüger M., Wehland M., Infanger M., Grimm D. The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure. Nutrients. 2019 Jul. 11(7). 1679. DOI: 10.3390/nu11071679.</mixed-citation><mixed-citation xml:lang="en">Khalaf D., Krüger M., Wehland M., Infanger M., Grimm D. The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure. Nutrients. 2019 Jul. 11(7). 1679. DOI: 10.3390/nu11071679.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Barkhidarian B., Khorshidi M., Shab-Bidar S., Hashemi B. Effects of L-citrulline supplementation on blood pressure : A systematic review and meta-analysis. Avicenna J Phytomed. 2019 Jan-Feb. 9(1). 10-20.</mixed-citation><mixed-citation xml:lang="en">Barkhidarian B., Khorshidi M., Shab-Bidar S., Hashemi B. Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna J Phytomed. 2019 Jan-Feb. 9(1). 10-20.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
