<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zabmedvestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Забайкальский медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Transbaikalian Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">1998-6173</issn><publisher><publisher-name>Читинская государственная медицинская академия</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52485/19986173_2023_1_122</article-id><article-id custom-type="elpub" pub-id-type="custom">zabmedvestnik-132</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS</subject></subj-group></article-categories><title-group><article-title>Кардиоваскулярные осложнения современных противоопухолевых препаратов (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Cardiovacular toxicity of modern cancer treatment (review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бусыгин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Busygin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>675000,; ул. Горького, 95; Благовещенск</p></bio><bio xml:lang="en"><p>675000; 95 Gorkogo srt.; Blagoveshchensk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Даниленко</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilenko</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>675000,; ул. Горького, 95; Благовещенск</p></bio><bio xml:lang="en"><p>675000; 95 Gorkogo srt.; Blagoveshchensk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайкова-Хелимская</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaykova-Khelimskaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>680000; ул. Муравьева-Амурского, д. 35; Хабаровск</p></bio><bio xml:lang="en"><p>680000; 35 Muravyov-Amursky str.; Khabarovsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурская государственная медицинская академия» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Amur State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования» Дальневосточный государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far Eastern State Medicalь University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>04</day><month>08</month><year>2024</year></pub-date><volume>0</volume><issue>1</issue><fpage>122</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бусыгин В.В., Даниленко С.А., Зайкова-Хелимская И.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Бусыгин В.В., Даниленко С.А., Зайкова-Хелимская И.В.</copyright-holder><copyright-holder xml:lang="en">Busygin V.V., Danilenko S.A., Zaykova-Khelimskaya I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zabmedvestnik.ru/jour/article/view/132">https://www.zabmedvestnik.ru/jour/article/view/132</self-uri><abstract><p>   Таргетнаяь терапия современными противоопухолевыми препаратами позволяет значительно улучшить прогноз у пациентов онкологического профиля. Кардиоваскулярные осложения такого лечения могут стать причиной преждевременной отмены лекарственных средств. В статье приводятся данные о наиболее часто встречающихся при применении различных классов противоопухолевых препаратов кардиоваскулярных нежелательных реакций, рассматриваются вопросы их патогенеза и диагностики.</p></abstract><trans-abstract xml:lang="en"><p>   Targeted therapy with modern cancer treatment can significantly improve the prognosis of survival for patients. Cardiovascular (CV) adverse events (AE) can lead to premature discontinuation of treatment. This article presents data on the most common cardiovascular AEs in the application of various classes of targeting therapy and discusses the issues of pathogenesis and diagnosis CV toxicity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиоваскулярные осложнения</kwd><kwd>противоопухолевые препараты</kwd><kwd>нежелательные явления</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular toxicity</kwd><kwd>cancer treatment</kwd><kwd>adverse events</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zamorano J.L., Lancellotti P., Rodriguez Muñoz D., et al.; ESC Scientific Document Group. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J. 2016 Sep 21;37(36):2768-2801. doi: 10.1093/eurheartj/ehw211. Epub 2016 Aug 26. Erratum in: Eur Heart J. 2016 Dec 24.</mixed-citation><mixed-citation xml:lang="en">Zamorano J.L., Lancellotti P., Rodriguez Muñoz D., et al.; ESC Scientific Document Group. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J. 2016 Sep 21;37(36):2768-2801. doi: 10.1093/eurheartj/ehw211. Epub 2016 Aug 26. Erratum in: Eur Heart J. 2016 Dec 24.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cancer Therapy Evaluation Program Adverse Event Reporting System [cited 2022 Dec 22]. Available from: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/adverse_events.htm</mixed-citation><mixed-citation xml:lang="en">Cancer Therapy Evaluation Program Adverse Event Reporting System [cited 2022 Dec 22]. Available from: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/adverse_events.htm</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Виценя М.В., Агеев Ф.Т., Гиляров М.Ю., Овчинников А.Г., Орлова Р.В., Полтавская М.Г. Практические рекомендации по коррекции кардиоваскулярной токсичности противоопухолевой лекарственной терапии. Злокачественные опухоли : Практические рекомендации RUSSCO #3s2, 2021 (том 11). 41.</mixed-citation><mixed-citation xml:lang="en">Vitsenya M.V., Ageev F.T., Gilyarov M.Yu., Ovchinnikov A.G., Orlova R.V., Poltavskaya M.G. Practical recommendations for the correction of cardiovascular toxicity of anticancer drug therapy. Malignant tumors: RUSSCO practice guidelines #3s2, 2021 (Vol. 11). 41. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Салахутдинова Л.М. Кардиотоксичность при лечении онкологических пациентов (обзор литературы). Поволжский онкологический вестник. 2022. № 2(50). С. 93-110.</mixed-citation><mixed-citation xml:lang="en">Salakhutdinova L. M. Cardiotoxicity in the treatment of cancer patients (literature review). Povolzhsky Oncological Bulletin. 2022. No. 2(50). pp. 93-110. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Liu S., Gao W., Ning Y., Zou X., Zhang W., Zeng L., Liu J. Cardiovascular Toxicity With PD-1/PD-L1 Inhibitors in Cancer Patients: A Systematic Review and Meta-Analysis. Front Immunol. 2022 Jul 8;13:908173. doi: 10.3389/fimmu.2022.908173.</mixed-citation><mixed-citation xml:lang="en">Liu S., Gao W., Ning Y., Zou X., Zhang W., Zeng L., Liu J. Cardiovascular Toxicity With PD-1/PD-L1 Inhibitors in Cancer Patients: A Systematic Review and Meta-Analysis. Front Immunol. 2022 Jul 8;13:908173. doi: 10.3389/fimmu.2022.908173.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А, Шупенина Е.Ю, Новосел Е.О., Агапов И.С. Нарушения ритма и проводимости сердца как проявления кардиотоксичности противоопухолевого лечения - миф или реальность? Сибирский медицинский журнал (г. Томск). 2020. Т. 35. № 1. С. 13-21. DOI: 10.29001/2073-8552-2020-35-1-13-21.</mixed-citation><mixed-citation xml:lang="en">Vasyuk Yu.A., Shupenina E.Yu., Novosel E.O., Agapov I.S. Heart rhythm and conduction disturbances as manifestations of cardiotoxicity of anticancer treatment - myth or reality? Siberian Medical Journal (Tomsk). 2020. V. 35. No. 1. S. 13-21. DOI: 10.29001/2073-8552-2020-35-1-13-21. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lyon A.R., López-Fernández T., Couch L.S., et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022 Nov 1;43(41):4229-4361. doi: 10.1093/eurheartj/ehac244.</mixed-citation><mixed-citation xml:lang="en">Lyon A.R., López-Fernández T., Couch L.S., et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022 Nov 1;43(41):4229-4361. doi: 10.1093/eurheartj/ehac244.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann J., Lenihan D., Armenian S., et al. Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement. Eur Heart J. 2022 Jan 31;43(4):280-299. doi: 10.1093/eurheartj/ehab674.</mixed-citation><mixed-citation xml:lang="en">Herrmann J., Lenihan D., Armenian S., et al. Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement. Eur Heart J. 2022 Jan 31;43(4):280-299. doi: 10.1093/eurheartj/ehab674.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Перепечко Д.Д. Лекарственно-индуцированная кардиотоксичность, ассоциированная с применением противоопухолевых антибиотиков. Кардиология: новости, мнения, обучение. 2021. Т. 9. № 1(26). С. 32-38. DOI: 10.33029/2309-1908-2021-9-1-32-38.</mixed-citation><mixed-citation xml:lang="en">Perepechko D. D. Drug-induced cardiotoxicity associated with the use of antitumor antibiotics. Cardiology: news, opinions, training. 2021. Vol. 9. No. 1(26). pp. 32-38. DOI 10.33029/2309-1908-2021-9-1-32-38. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobs J.E.J., Guler I., Duchenne J., Janssens S., Van Aelst L.N.L. Predictability of cardiotoxicity: Experience of a Belgian cardio-oncology clinic. Int J Cardiol. 2022 Sep 15;363:119-122. doi: 10.1016/j.ijcard.2022.06.063. Epub 2022 Jun 28.</mixed-citation><mixed-citation xml:lang="en">Jacobs J.E.J., Guler I., Duchenne J., Janssens S., Van Aelst L.N.L. Predictability of cardiotoxicity: Experience of a Belgian cardio-oncology clinic. Int J Cardiol. 2022 Sep 15;363:119-122. doi: 10.1016/j.ijcard.2022.06.063. Epub 2022 Jun 28.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Desai A., Noor A., Joshi S., Kim A.S. Takotsubo cardiomyopathy in cancer patients. Cardiooncology. 2019 Jul 1;5:7. doi: 10.1186/s40959-019-0042-9.</mixed-citation><mixed-citation xml:lang="en">Desai A., Noor A., Joshi S., Kim A.S. Takotsubo cardiomyopathy in cancer patients. Cardiooncology. 2019 Jul 1;5:7. doi: 10.1186/s40959-019-0042-9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shah C.P., Moreb J.S. Cardiotoxicity due to targeted anticancer agents: a growing challenge. Ther Adv Cardiovasc Dis. 2019 Jan-Dec;13:1753944719843435. doi: 10.1177/1753944719843435.</mixed-citation><mixed-citation xml:lang="en">Shah C.P., Moreb J.S. Cardiotoxicity due to targeted anticancer agents: a growing challenge. Ther Adv Cardiovasc Dis. 2019 Jan-Dec;13:1753944719843435. doi: 10.1177/1753944719843435.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Nhola L.F., Abdelmoneim S.S., Villarraga H.R., et al. Echocardiographic Assessment for the Detection of Cardiotoxicity Due to Vascular Endothelial Growth Factor Inhibitor Therapy in Metastatic Renal Cell and Colorectal Cancers. J Am Soc Echocardiogr. 2019 Feb;32(2):267-276. doi: 10.1016/j.echo.2018.09.019. Epub 2018 Nov 17.</mixed-citation><mixed-citation xml:lang="en">Nhola L.F., Abdelmoneim S.S., Villarraga H.R., et al. Echocardiographic Assessment for the Detection of Cardiotoxicity Due to Vascular Endothelial Growth Factor Inhibitor Therapy in Metastatic Renal Cell and Colorectal Cancers. J Am Soc Echocardiogr. 2019 Feb;32(2):267-276. doi: 10.1016/j.echo.2018.09.019. Epub 2018 Nov 17.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pandey A.K., Singhi E.K., Arroyo J.P., et al. Mechanisms of VEGF (Vascular Endothelial Growth Factor) Inhibitor-Associated Hypertension and Vascular Disease. Hypertension. 2018 Feb;71(2):e1-e8. doi: 10.1161/HYPERTENSIONAHA.117.10271. Epub 2017 Dec 26.</mixed-citation><mixed-citation xml:lang="en">Pandey A.K., Singhi E.K., Arroyo J.P., et al. Mechanisms of VEGF (Vascular Endothelial Growth Factor) Inhibitor-Associated Hypertension and Vascular Disease. Hypertension. 2018 Feb;71(2):e1-e8. doi: 10.1161/HYPERTENSIONAHA.117.10271. Epub 2017 Dec 26.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Alexandre J., Salem J.E., Moslehi J., et al. Identification of anticancer drugs associated with atrial fibrillation: analysis of the WHO pharmacovigilance database. Eur Heart J Cardiovasc Pharmacother. 2021 Jul 23;7(4):312-320. doi: 10.1093/ehjcvp/pvaa037.</mixed-citation><mixed-citation xml:lang="en">Alexandre J., Salem J.E., Moslehi J., et al. Identification of anticancer drugs associated with atrial fibrillation: analysis of the WHO pharmacovigilance database. Eur Heart J Cardiovasc Pharmacother. 2021 Jul 23;7(4):312-320. doi: 10.1093/ehjcvp/pvaa037.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">McDonagh T.A., Metra M., Adamo M., et al.; ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726. doi: 10.1093/eurheartj/ehab368. Erratum in: Eur Heart J. 2021 Oct 14.</mixed-citation><mixed-citation xml:lang="en">McDonagh T.A., Metra M., Adamo M., et al.; ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726. doi: 10.1093/eurheartj/ehab368. Erratum in: Eur Heart J. 2021 Oct 14.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B., Mancia G., Spiering W., et al; ESC Scientific Document Group. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018 Sep 1;39(33):3021-3104. doi: 10.1093/eurheartj/ehy339. Erratum in: Eur Heart J. 2019 Feb 1;40(5):475.</mixed-citation><mixed-citation xml:lang="en">Williams B., Mancia G., Spiering W., et al; ESC Scientific Document Group. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018 Sep 1;39(33):3021-3104. doi: 10.1093/eurheartj/ehy339. Erratum in: Eur Heart J. 2019 Feb 1;40(5):475.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Barber M.C., Mauro M.J., Moslehi J. Cardiovascular care of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) therapy. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):110-114. doi: 10.1182/asheducation-2017.1.110.</mixed-citation><mixed-citation xml:lang="en">Barber M.C., Mauro M.J., Moslehi J. Cardiovascular care of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) therapy. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):110-114. doi: 10.1182/asheducation-2017.1.110.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Buza V., Rajagopalan B., Curtis A.B. Cancer Treatment-Induced Arrhythmias: Focus on Chemotherapy and Targeted Therapies. Circ Arrhythm Electrophysiol. 2017 Aug;10(8):e005443. doi: 10.1161/CIRCEP.117.005443.</mixed-citation><mixed-citation xml:lang="en">Buza V., Rajagopalan B., Curtis A.B. Cancer Treatment-Induced Arrhythmias: Focus on Chemotherapy and Targeted Therapies. Circ Arrhythm Electrophysiol. 2017 Aug;10(8):e005443. doi: 10.1161/CIRCEP.117.005443.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann J, Yang E.H., Iliescu C.A., et al. Vascular Toxicities of Cancer Therapies: The Old and the New--An Evolving Avenue. Circulation. 2016 Mar 29;133(13):1272-89. doi: 10.1161/CIRCULATIONAHA.115.018347.</mixed-citation><mixed-citation xml:lang="en">Herrmann J, Yang E.H., Iliescu C.A., et al. Vascular Toxicities of Cancer Therapies: The Old and the New--An Evolving Avenue. Circulation. 2016 Mar 29;133(13):1272-89. doi: 10.1161/CIRCULATIONAHA.115.018347.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Postow M.A., Sidlow R., Hellmann M.D. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018 Jan 11;378(2):158-168. doi: 10.1056/NEJMra1703481.</mixed-citation><mixed-citation xml:lang="en">Postow M.A., Sidlow R., Hellmann M.D. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018 Jan 11;378(2):158-168. doi: 10.1056/NEJMra1703481.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Drobni Z.D., Alvi R.M., Taron J., et al. Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque. Circulation. 2020 Dec 15;142(24):2299-2311. doi: 10.1161/CIRCULATIONAHA.120.049981. Epub 2020 Oct 2.</mixed-citation><mixed-citation xml:lang="en">Drobni Z.D., Alvi R.M., Taron J., et al. Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque. Circulation. 2020 Dec 15;142(24):2299-2311. doi: 10.1161/CIRCULATIONAHA.120.049981. Epub 2020 Oct 2.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Rubio-Infante N., Ramírez-Flores Y.A., Castillo E.C., Lozano O., García-Rivas G., Torre-Amione G. Cardiotoxicity associated with immune checkpoint inhibitor therapy: a meta-analysis. Eur J Heart Fail. 2021 Oct;23(10):1739-1747. doi: 10.1002/ejhf.2289. Epub 2021 Jul 29.</mixed-citation><mixed-citation xml:lang="en">Rubio-Infante N., Ramírez-Flores Y.A., Castillo E.C., Lozano O., García-Rivas G., Torre-Amione G. Cardiotoxicity associated with immune checkpoint inhibitor therapy: a meta-analysis. Eur J Heart Fail. 2021 Oct;23(10):1739-1747. doi: 10.1002/ejhf.2289. Epub 2021 Jul 29.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Dolladille C., Akroun J., Morice P.M., et al. Cardiovascular immunotoxicities associated with immune checkpoint inhibitors: a safety meta-analysis. Eur Heart J. 2021 Dec 21;42(48):4964-4977. doi: 10.1093/eurheartj/ehab618.</mixed-citation><mixed-citation xml:lang="en">Dolladille C., Akroun J., Morice P.M., et al. Cardiovascular immunotoxicities associated with immune checkpoint inhibitors: a safety meta-analysis. Eur Heart J. 2021 Dec 21;42(48):4964-4977. doi: 10.1093/eurheartj/ehab618.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lehmann L.H., Cautela J., Palaskas N., et al. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis : A Narrative Review. JAMA Cardiol. 2021 Nov 1;6(11):1329-1337. doi: 10.1001/jamacardio.2021.2241.</mixed-citation><mixed-citation xml:lang="en">Lehmann L.H., Cautela J., Palaskas N., et al. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis : A Narrative Review. JAMA Cardiol. 2021 Nov 1;6(11):1329-1337. doi: 10.1001/jamacardio.2021.2241.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Awadalla M., Mahmood S.S., Groarke J.D., et al. Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis. J Am Coll Cardiol. 2020 Feb 11;75(5):467-478. doi: 10.1016/j.jacc.2019.11.049.</mixed-citation><mixed-citation xml:lang="en">Awadalla M., Mahmood S.S., Groarke J.D., et al. Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis. J Am Coll Cardiol. 2020 Feb 11;75(5):467-478. doi: 10.1016/j.jacc.2019.11.049.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Кулиева А.А., Емелина Е.И., Гендлин Г.Е. Сердечно-сосудистые осложнения терапии ингибиторами контрольных точек иммунитета. Качественная клиническая практика. 2019. № 4. С. 55-65. URL: https://cyberleninka.ru/article/n/serdechno-sosudistye-oslozhneniya-terapii-ingibitorami-kontrolnyh-tochek-immuniteta.</mixed-citation><mixed-citation xml:lang="en">Kulieva A.A., Emelina E.I., Gendlin G.E. Cardiovascular complications of therapy with immune checkpoint inhibitors. Quality clinical practice. 2019. No. 4. S. 55-65. URL: https://cyberleninka.ru/article/n/serdechno-sosudistye-oslozhneniya-terapii-ingibitorami-kontrolnyh-tochek-immuniteta. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Salem J.E., Manouchehri A., Bretagne M., et al. Cardiovascular Toxicities Associated With Ibrutinib. J Am Coll Cardiol. 2019 Oct 1;74(13):1667-1678. doi: 10.1016/j.jacc.2019.07.056.</mixed-citation><mixed-citation xml:lang="en">Salem J.E., Manouchehri A., Bretagne M., et al. Cardiovascular Toxicities Associated With Ibrutinib. J Am Coll Cardiol. 2019 Oct 1;74(13):1667-1678. doi: 10.1016/j.jacc.2019.07.056.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Brown J.R., Byrd J.C., Ghia P., et al. Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients. Haematologica. 2022 Jun 1;107(6):1335-1346. doi: 10.3324/haematol.2021.278901.</mixed-citation><mixed-citation xml:lang="en">Brown J.R., Byrd J.C., Ghia P., et al. Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients. Haematologica. 2022 Jun 1;107(6):1335-1346. doi: 10.3324/haematol.2021.278901.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Авалян А.А., Саидова М.А., Ощепкова Е.В., Чазова И.Е. Современные подходы к выявлению ранней субклинической кардиотоксичности, индуцированной химиотерапией, у больных раком молочной железы. Евразийский кардиологический журнал. 2018. № 3. С. 50-61.</mixed-citation><mixed-citation xml:lang="en">Avalyan A.A., Saidova M.A., Oshchepkova E.V., Chazova I.Ye. Modern approaches to detecting early subclinical cardiotoxicity induced by chemotherapy in patients with breast cancer. Eurasian cardiological journal. 2018, September 20; 3: 56-61. in Russian.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Eiger D., Pondé N.F., Agbor-Tarh D., et al. Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial. Br J Cancer. 2020 May;122(10):1453-1460. doi: 10.1038/s41416-020-0786-x. Epub 2020 Mar 16.</mixed-citation><mixed-citation xml:lang="en">Eiger D., Pondé N.F., Agbor-Tarh D., et al. Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial. Br J Cancer. 2020 May;122(10):1453-1460. doi: 10.1038/s41416-020-0786-x. Epub 2020 Mar 16.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Martel S., Maurer C., Lambertini M., Pondé N., De Azambuja E. Breast cancer treatment-induced cardiotoxicity. Expert Opin Drug Saf. 2017 Sep;16(9):1021-1038. doi: 10.1080/14740338.2017.1351541. Epub 2017 Jul 18.</mixed-citation><mixed-citation xml:lang="en">Martel S., Maurer C., Lambertini M., Pondé N., De Azambuja E. Breast cancer treatment-induced cardiotoxicity. Expert Opin Drug Saf. 2017 Sep;16(9):1021-1038. doi: 10.1080/14740338.2017.1351541. Epub 2017 Jul 18.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lyon A.R., Dent S., Stanway S., et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020 Nov;22(11):1945-1960. doi: 10.1002/ejhf.1920. Epub 2020 Aug 6.</mixed-citation><mixed-citation xml:lang="en">Lyon A.R., Dent S., Stanway S., et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020 Nov;22(11):1945-1960. doi: 10.1002/ejhf.1920. Epub 2020 Aug 6.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sara J.D., Kaur J., Khodadadi R., et al. 5-fluorouracil and cardiotoxicity : a review. Ther Adv Med Oncol. 2018 Jun 18;10:1758835918780140. doi: 10.1177/1758835918780140.</mixed-citation><mixed-citation xml:lang="en">Sara J.D., Kaur J., Khodadadi R., et al. 5-fluorouracil and cardiotoxicity : a review. Ther Adv Med Oncol. 2018 Jun 18;10:1758835918780140. doi: 10.1177/1758835918780140.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Čelutkienė J., Pudil R., López-Fernández T., et al. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC). Eur J Heart Fail. 2020 Sep;22(9):1504-1524. doi: 10.1002/ejhf.1957. Epub 2020 Aug 21. Erratum in: Eur J Heart Fail. 2021 Feb;23(2):345.</mixed-citation><mixed-citation xml:lang="en">Čelutkienė J., Pudil R., López-Fernández T., et al. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC). Eur J Heart Fail. 2020 Sep;22(9):1504-1524. doi: 10.1002/ejhf.1957. Epub 2020 Aug 21. Erratum in: Eur J Heart Fail. 2021 Feb;23(2):345.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatia N., Santos M., Jones L.W., Beckman J.A., Penson D.F., Morgans A.K., Moslehi J. Cardiovascular Effects of Androgen Deprivation Therapy for the Treatment of Prostate Cancer: ABCDE Steps to Reduce Cardiovascular Disease in Patients With Prostate Cancer. Circulation. 2016 Feb 2;133(5):537-41. doi: 10.1161/CIRCULATIONAHA.115.012519.</mixed-citation><mixed-citation xml:lang="en">Bhatia N., Santos M., Jones L.W., Beckman J.A., Penson D.F., Morgans A.K., Moslehi J. Cardiovascular Effects of Androgen Deprivation Therapy for the Treatment of Prostate Cancer: ABCDE Steps to Reduce Cardiovascular Disease in Patients With Prostate Cancer. Circulation. 2016 Feb 2;133(5):537-41. doi: 10.1161/CIRCULATIONAHA.115.012519.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Visseren F.L.J., Mach F., Smulders Y.M., et al.; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337. doi: 10.1093/eurheartj/ehab484. Erratum in: Eur Heart J. 2022 Nov 7;43(42):4468.</mixed-citation><mixed-citation xml:lang="en">Visseren F.L.J., Mach F., Smulders Y.M., et al.; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337. doi: 10.1093/eurheartj/ehab484. Erratum in: Eur Heart J. 2022 Nov 7;43(42):4468.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Shore N.D., Saad F., Cookson M.S., et al.; HERO Study Investigators. Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer. N Engl J Med. 2020 Jun 4;382(23):2187-2196. doi: 10.1056/NEJMoa2004325. Epub 2020 May 29.</mixed-citation><mixed-citation xml:lang="en">Shore N.D., Saad F., Cookson M.S., et al.; HERO Study Investigators. Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer. N Engl J Med. 2020 Jun 4;382(23):2187-2196. doi: 10.1056/NEJMoa2004325. Epub 2020 May 29.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Okwuosa T.M., Morgans A., Rhee J.W., et al. American Heart Association Cardio-Oncology Subcommittee of the Council on Clinical Cardiology and the Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Cardiovascular Radiology and Intervention. Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System: Effects and Modifications: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2021 Jun;14(3):e000082. doi: 10.1161/HCG.0000000000000082. Epub 2021 Apr 26.</mixed-citation><mixed-citation xml:lang="en">Okwuosa T.M., Morgans A., Rhee J.W., et al. American Heart Association Cardio-Oncology Subcommittee of the Council on Clinical Cardiology and the Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Cardiovascular Radiology and Intervention. Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System: Effects and Modifications: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2021 Jun;14(3):e000082. doi: 10.1161/HCG.0000000000000082. Epub 2021 Apr 26.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Salem J.E., Waintraub X., Courtillot C., et al. Hypogonadism as a Reversible Cause of Torsades de Pointes in Men. Circulation. 2018 Jul 3;138(1):110-113. doi: 10.1161/CIRCULATIONAHA.118.034282.</mixed-citation><mixed-citation xml:lang="en">Salem J.E., Waintraub X., Courtillot C., et al. Hypogonadism as a Reversible Cause of Torsades de Pointes in Men. Circulation. 2018 Jul 3;138(1):110-113. doi: 10.1161/CIRCULATIONAHA.118.034282.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
