zabmedvestnikЗабайкальский медицинский вестникTransbaikalian Medical Bulletin1998-6173Читинская государственная медицинская академия10.52485/19986173_2022_4_107zabmedvestnik-106Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSИшемический инсульт как генетически обусловленное заболеваниеIschemic stroke as a genetical diseaseМа-Ван-дэА. Ю.Ma-Van-deA. Yu.

672000, г. Чита., ул. Горького, 39А

39 A Gorkogo str., Chita, 672000

ВитковскийЮ. А.VitkovskyYu. A.

672000, г. Чита., ул. Горького, 39А

39 A Gorkogo str., Chita, 672000

Федеральное государственное бюджетное образовательное учреждение высшего образования «Читинская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияChita State Medical AcademyRussian Federation20220208202404107113Copyright © Ма-Ван-дэ А.Ю., Витковский Ю.А., 20242024Ма-Ван-дэ А.Ю., Витковский Ю.А.Ma-Van-de A., Vitkovsky Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zabmedvestnik.ru/jour/article/view/106

Ишемический инсульт является мультифакториальным заболеванием, патогенез которого тесно связан с генетической предрасположенностью. Результаты проведенных исследований свидетельствуют о повышенном риске развития ишемического инсульта при наличии отягощённого семейного анамнеза. Установлено, что развитие острой церебральной ишемии в возрасте до 65 лет повышает риск возникновения острого нарушения мозгового кровообращения у ближайших родственников в 4 раза. Также известно, что инсульт, возникший в молодом возрасте, в большей степени связан с носительством различных генетических полиморфизмов, нежели с наличием факторов сердечно-сосудистого риска. В обзоре литературы представлены современные данные по острой цереброваскулярной патологии и ее связи с носительством различными полиморфных вариантов генов: ренин-ангиотензин-альдостероновой системы (РААС), генов, регулирующих функцию эндотелия, фолатный обмен, ионные каналы.

Ischemic stroke is a multifactorial disease, the pathogenesis of which is closely related to genetic predisposition. The results of the conducted studies indicate an increased risk of ischemic stroke in the presence of an aggravated family history. It has been established that the development of acute cerebral ischemia under the age of 65 increases the risk of acute cerebrovascular accident in the next of kin by 4 times. It is also known that stroke occurring at a young age is more associated with the carriage of various genetic polymorphisms than with the presence of cardiovascular risk factors.

The literature review presents current data on acute cerebrovascular pathology and its relationship with the carriage of various polymorphic variants of genes: the renin-angiotensin-aldosterone system (RAAS), genes that regulate endothelial function, folate metabolism, and ion channels.

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The authors declare that there are no conflicts of interest present.